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Tyrosine Phosphorylation Based Homo-Dimerization Of Arabidopsis Rack1a Proteins Regulates Oxidative Stress Signaling Pathways In Yeast, Mercy H. Sabila, Nabanita Kundu, Deana Smalls, Hemayet Ullah
Tyrosine Phosphorylation Based Homo-Dimerization Of Arabidopsis Rack1a Proteins Regulates Oxidative Stress Signaling Pathways In Yeast, Mercy H. Sabila, Nabanita Kundu, Deana Smalls, Hemayet Ullah
Hemayet Ullah
Scaffold proteins are known as important cellular regulators that can interact with multiple proteins to modulate diverse signal transduction pathways. RACK1 (Receptor for Activated C Kinase 1) is a WD-40 type scaffold protein, conserved in eukaryotes, from Chlamydymonas to plants and humans, plays regulatory roles in diverse signal transduction and stress response pathways. RACK1 in humans has been implicated in myriads of neuropathological diseases including Alzheimer and alcohol addictions. Model plant Arabidopsis thaliana genome maintains three different RACK1 genes termed RACK1A, RACK1B, and RACK1C with a very high (85-93%) sequence identity between them. Loss of function mutant in Arabidopsis indicates …