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Genetic And Biochemical Characterization Of Ergot Alkaloid Synthesizing Fungi And Their Symbionts, Matthew Duane Maust
Genetic And Biochemical Characterization Of Ergot Alkaloid Synthesizing Fungi And Their Symbionts, Matthew Duane Maust
Graduate Theses, Dissertations, and Problem Reports
Ergot alkaloids are fungal tryptophan derived toxins which affect mammalian circulation and neurotransmission. These compounds are biosynthesized by a conserved genetic pathway, known as the ergot alkaloid synthesis (EAS) pathway by fungi belonging to the ascomycete families Trichocomaceae and Clavicipitaceae. Several Ipomoea species and related plants in the morning glory family harbor vertically transmitted symbiotic fungi in the genus Periglandula, also members of Clavicipitaceae, that produce ergot alkaloids. Metabolomic analysis of seeds identified a previously uncharacterized glycoside form of the pharmaceutically important ergot alkaloid, ergonovine. Several species belonging to the fungal genus Metarhizium have recently been shown to have the …
Occurrence, Mating Strategy, And Pathogenicity Of Members Of Nectriaceae In Central Appalachia, Cameron Michael Stauder
Occurrence, Mating Strategy, And Pathogenicity Of Members Of Nectriaceae In Central Appalachia, Cameron Michael Stauder
Graduate Theses, Dissertations, and Problem Reports
Members of the Nectriaceae occupy many ecological niches including dominant canker pathogens, such as Neonectria ditissima and N. faginata. These two pathogens contribute to the decline of American beech (Fagus grandifolia) forests across the Appalachian Mountains due to beech bark disease (BBD). Interestingly, N. ditissima represents a well-known canker pathogen many hardwood species, while N. faginata has not been observed outside of BBD. Additionally, N. faginata occurs at higher incidences than N. ditissima in BBD stands. Nectriaceae in Central Appalachia were surveyed as to further characterize the diversity and possibly identify a non-beech host of N. faginata. …