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Signaling Via Camp In Fungi: Interconnections With Mitogen-Activated Protein Kinase Pathways, James Kronstad, Adriana De Maria, Deanna L. Funnell, R. David Laidlaw, Nancy Lee, Mário Moniz De Sá, Marilee Ramesh

Department of Plant Pathology: Faculty Publications

The cAMP signal transduction pathway controls a wide variety of processes in fungi. For example, considerable progress has been made in describing the involvement of cAMP pathway components in the control of morphogenesis in Saccharomyces cerevisiae, Ustilago maydis, and Magnaporthe grisea. These morphological processes include the establishment of filamentous growth in S. cerevisiae and U. maydis, and the differentiation of an appressorial infection structure in M. grisea. The discovery that appressorium formation requires cAMP signaling provides an immediate connection to fungal virulence. This connection may have broader implications among fungal pathogens because recent work indicates that …