Life Sciences Commons^™

Novel Systems For The Functional Characterization Of Genes Related To Paclitaxel Metabolism In Taxus Cell Cultures, Khamkeo Vongpaseuth

Open Access Dissertations

Human society has benefited greatly from plant secondary metabolites, often utilizing a variety of compounds as dyes, food additives, and drugs. In particular, pharmaceutical development has benefited greatly from plant secondary metabolites. One example of this utility is paclitaxel, a highly substituted diterpene approved in the treatment of breast cancer, ovarian cancer, non-small cell lung cancer, and the AIDSrelated Kaposi’s sarcoma. Demand of paclitaxel is likely to increase, due to the current examination of paclitaxel in numerous clinical trials against a variety of other cancers.

Taxus cell culture represents a production source of paclitaxel to meet future demand. However, paclitaxel …