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Full-Text Articles in Life Sciences
Regulation Of Trophoblast Invasion By Pyruvate Kinase Isozyme M2 (Pkm2): Preemptive To Pkm2 Activation Decreases Iugr Symptoms In Mice Exposed To Second-Hand Smoke, Juan Mejia, Juan Arroyo, Ph.D.
Regulation Of Trophoblast Invasion By Pyruvate Kinase Isozyme M2 (Pkm2): Preemptive To Pkm2 Activation Decreases Iugr Symptoms In Mice Exposed To Second-Hand Smoke, Juan Mejia, Juan Arroyo, Ph.D.
Journal of Undergraduate Research
The placenta is an organ composed of highly vascular tissue. It plays an essential role in healthy fetal development as a mediator of gases and nutrients between the mother and fetus. Many complications can occur in this stage of fetal development, such as intrauterine growth restriction (IUGR) when the placenta’s invasive and vascular roles are inhibited. IUGR is an obstetric complication that affects over 10% of the population causing harmful symptoms to the fetus and mother. Physiologically, in the first trimester, high trophoblast cell invasion occurs, and the spiral arteries dilate to create a low resistance, high capacity vessel capable …
Antenatal Exposure To Secondhand Smoke Impacts Growth And Cardiopulmonary Energetics In 4-Week-Old Mice, Kaleb Egbert, Paul Reynolds
Antenatal Exposure To Secondhand Smoke Impacts Growth And Cardiopulmonary Energetics In 4-Week-Old Mice, Kaleb Egbert, Paul Reynolds
Journal of Undergraduate Research
Secondhand smoke (SHS) is a well-established cause of respiratory illness in infants and children who live in environments where exposure is common. Recent studies have been performed to examine the potential effects of SHS exposure on fetus’s before they are born1. The data collected suggests that antenatal exposure to SHS impacts cardiovascular and respiratory function through childhood and may even have lifelong ramifications, even if the exposure is terminated shortly after birth. In our study, we sought to determine the impact of SHS exposure during development in the womb would have on 4 week-old mice, or the equivalent of an …
The Biology Of Claudin 6 (Cldn6) In The Developing Mouse Lung, Felix Ruben Jimenez Rondan
The Biology Of Claudin 6 (Cldn6) In The Developing Mouse Lung, Felix Ruben Jimenez Rondan
Theses and Dissertations
The tight junctions (TJ), which are located in the apical region between epithelial and endothelial cells, regulate the paracellular diffusion of ions and small molecules and play an important role in maintaining cell polarity, cell-cell integrity, and permeability. In the lung, epithelial cells are attached by TJ structures. They provide a permeable barrier and cell communication. The loss of barrier integrity, which is maintained by the expression of claudins (Cldn), results in cellular permibilization and leads to paracellular diffusion of solutes and harmful molecules. There are 27 known Cldn homologous members in mice and human. Cldn6 is mostly expressed in …
Expression Of Osteoarthritis Biomarkers In Temporomandibular Joints Of Mice With And Without Receptor For Advanced Glycation End Products (Rage), Elizabeth Murayama Chavez Matias
Expression Of Osteoarthritis Biomarkers In Temporomandibular Joints Of Mice With And Without Receptor For Advanced Glycation End Products (Rage), Elizabeth Murayama Chavez Matias
Theses and Dissertations
This thesis will be organized into three chapters discussing the mechanism underlying the onset and progression of osteoarthritis (OA) in the temporomandibular joint (TMJ). Understanding the mechanism of OA development in the TMJ helps in understanding how OA progresses and how to treat this disease. The goal of this investigation is to examine the process of cartilage degeneration and OA biomarker expression in the TMJ to understand their role in TMJ OA onset and development.Chapter one covers mechanisms that are altered in TMJ OA during disease progression. Using animal models with different stressors such as mechanical disturbances, direct injury, and …