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Expression And Regulation Of Osteopontin In The Diabetic Heart, Abigail Goodman
Expression And Regulation Of Osteopontin In The Diabetic Heart, Abigail Goodman
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Diabetes leads to several alterations in cardiac structure, one of which is fibrosis of the ventricular myocardium. Myocardial fibrosis is a common underlying factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. In the heart, the expression of OPN protein is increased after acute and chronic pathologies. Upregulation of OPN coincides with a transition to heart failure and a direct role for OPN in the progression of diabetic cardiomyopathy to heart failure has been reported.
The overall objective of this project is to determine if OPN is upregulated in the …