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Morphological And Functional Evidence Of Sexual Dimorphism In The Retrochiasmatic Area Population Of Nk3r-Containing Neurons In Sheep, Justin A. Lopez
Morphological And Functional Evidence Of Sexual Dimorphism In The Retrochiasmatic Area Population Of Nk3r-Containing Neurons In Sheep, Justin A. Lopez
Graduate Theses, Dissertations, and Problem Reports
Neurokinin B (NKB) and kisspeptin are critical for fertility and potent stimulators of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in sheep. We previously demonstrated that administration of NKB receptor (NK3R) agonist, senktide, within the retrochiasmatic area (RCh) resulted in surge-like release of LH and increased expression of kisspeptin neurons in the arcuate nucleus (ARC) of female lambs. We concluded that NKB-responsive neurons in the RCh stimulate GnRH secretion by inducing kisspeptin release from neurons in the ARC.
We have demonstrated morphological and functional evidence of sexual dimorphism in NKB-NK3R signaling in ovine RCh. RCh senktide administration resulted in …