Life Sciences Commons^™

Molecular Events In The Cell Types Of The Olfactory Epithelium During Adult Neurogenesis, Paula M. Heron, Arnold J. Stromberg, Patrick Breheny, Timothy S. Mcclintock

Physiology Faculty Publications

BACKGROUND: Adult neurogenesis, fundamental for cellular homeostasis in the mammalian olfactory epithelium, requires major shifts in gene expression to produce mature olfactory sensory neurons (OSNs) from multipotent progenitor cells. To understand these dynamic events requires identifying not only the genes involved but also the cell types that express each gene. Only then can the interrelationships of the encoded proteins reveal the sequences of molecular events that control the plasticity of the adult olfactory epithelium.

RESULTS: Of 4,057 differentially abundant mRNAs at 5 days after lesion-induced OSN replacement in adult mice, 2,334 were decreased mRNAs expressed by mature OSNs. Of the …

Developmental Changes In Postural Stability During The Performance Of A Precision Manual Task, Jeffrey M. Haddad, Laura J. Claxton, Dawn Melzer, Joseph Hamill, Richard E. A. Van Emmerik

Psychology Faculty Publications

Posture becomes integrated with other goal-directed behaviors early in infancy and continues to develop into the second decade of life. However, the developmental time course over which posture is stabilized relative to the base of support during a dynamic manual precision task has not been examined. Postural-manual integration was assessed in 7-year-olds, 10-year-olds, and adults using a postural-manual task in which task precision (target fitting size) and postural difficulty (reaching distance to a target) were manipulated. The main dependent variable was postural time-to-contact (TtC). Results indicated systematic age effects in which TtC was shortest in the 7-year-olds, increased in the …

Developmental Adaptation Hypothesis : Aerobic Capacity, Submaximal Arterial Saturation And Pulmonary Volumes In Peruvian Quechua Natives, Melisa Kiyamu Tsuchiya

Legacy Theses & Dissertations (2009 - 2024)

The Quechua populations have inhabited the Andes for hundreds of generations. The ability to thrive in this hostile environment, leading an active and healthy life has generated research questions about the special phenotype of Andean highlanders compared to their sea-level counterparts, such as their higher pulmonary volumes and their outstanding work capacity in spite of the challenge of oxygen transport and delivery in hypoxia. In high altitude natives, there have been two main explanations for the origins of the aforementioned traits: genetic adaptation through natural selection and developmental adaptation through the exposure to hypoxia during growth.