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Full-Text Articles in Life Sciences
Effects Of Resistance Exercise On Postprandial Metabolism In Obese Men With Prediabetes, Adam Bittel
Effects Of Resistance Exercise On Postprandial Metabolism In Obese Men With Prediabetes, Adam Bittel
Arts & Sciences Electronic Theses and Dissertations
Prediabetes is a metabolic condition defined by elevated fasting (impaired fasting glucose (IFG)) and/or postprandial (impaired glucose tolerance (IGT)) glucose. Prediabetes affects nearly 86 million adults in the United States, with most (up to 70%) progressing to type 2 diabetes within as little as one year. Recent studies have indicated that elevated post-prandial glycemia and hypertriglyceridemia are early indicators of prediabetes, and are major risk factors for complications of prediabetes, including cardiovascular disease (CVD), stroke, elevated blood pressure, and obesity. Resistance exercise is a central component of exercise recommendations for individuals with type 2 diabetes and prediabetes, but the effect …
Role Of Ataxia-Telangiectasia Mutated Kinase In Cardiac Autophagy And Glucose Metabolism Under Ischemic Conditions, Patsy Thrasher
Role Of Ataxia-Telangiectasia Mutated Kinase In Cardiac Autophagy And Glucose Metabolism Under Ischemic Conditions, Patsy Thrasher
Electronic Theses and Dissertations
Ataxia-telangiectasia mutated kinase (ATM), a serine/threonine kinase primarily located in the nucleus, is typically activated in response to DNA damage. Individuals with mutations in ATM gene develop a disease called Ataxia telangiectasia (AT). These individuals are more susceptible to ischemic heart disease and metabolic disorder. Our lab has previously shown that ATM plays a critical role in β-adrenergic receptor (β-AR) - and myocardial infarction (MI)-stimulated myocyte apoptosis and cardiac remodeling. This study tested the hypothesis that ATM plays a critical role in cardiac autophagy and glucose metabolism following MI and ischemia, respectively. Early during MI (4 hours after its onset) …