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- Acetyl-CoA (1)
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- Fatty acid oxidation (1)
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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Phosphorylation Of Skeletal Muscle Acetyl-Coa Carboxylase By Ampk Enhances Palmitoyl-Coa Inhibition, Dustin S. Rubink
Phosphorylation Of Skeletal Muscle Acetyl-Coa Carboxylase By Ampk Enhances Palmitoyl-Coa Inhibition, Dustin S. Rubink
Theses and Dissertations
Acetyl-CoA carboxylase (ACC) catalyzes the formation of malnoyl-CoA, which in turn controls the rate of fatty acid metabolism. ACC beta or 2 has been shown to be localized on the mitochondria in close proximity to carnintine palmitoyl transferase 1 (CPT-1), the enzyme responsible for the influx of acyl-CoA into the matrix where beta oxidation takes place. CPT-1 is inhibited by malonyl-CoA produced by ACC. It has been well documented that AMP activated kinase (AMPK) when activated phosphorylates and inactivates ACC. ACC is controlled allosterically by citrate, which activates, and by palmitoyl-COA, which inhibits. In this study, we asked the question, …
Mechanism Governing The Cellular Susceptibility To Secretory Phospholipase A2, Lauren Blackburn Jensen
Mechanism Governing The Cellular Susceptibility To Secretory Phospholipase A2, Lauren Blackburn Jensen
Theses and Dissertations
Secretory phospholipase A2 (sPLA2) is an important part of apoptosis and disposal of damaged and dying cells. However, healthy cells are not susceptible to attack by sPLA2. Recent studies have focused on membrane properties necessary to induce susceptibility in both artificial and biological membranes. Hydrolysis of phospholipids by sPLA2 requires at least two preliminary steps: first, adsorption of the enzyme to the cellular membrane, and second, movement of a phospholipid into the active site of the enzyme. We determined the effects of susceptibility on each of the two steps and determined the contributions changing the equilibrium constants have on susceptibility. …
Regulation Of Ca2+-Activated K+ Channel: Changes With Development, Mike T. Lin
Regulation Of Ca2+-Activated K+ Channel: Changes With Development, Mike T. Lin
Loma Linda University Electronic Theses, Dissertations & Projects
In ovine middle cerebral arteries, it has been shown that the [Ca2+]i change in response to iberiotoxin, a selective BK channel blocker, is significantly different between adult and fetal VSMCs. Our study of basilar VSMCs in whole-cell preparations showed that the total outward current density of fetal myocytes (57.9 ± 6.7 pA/pF) was greater than that of the adult (37.9 ±1.8 pA/pF). This increase in outward current density is contributed by an increase in BK channel current density in fetal myocytes. Excised, inside-out preparations showed that the unitary conductance, as well as the BK channel expression, did …
The Effects Of Plyometrics Training On Neuromuscular Responses And Ground Reaction Forces Surrounding The Knee, Barbara Mcdowell
The Effects Of Plyometrics Training On Neuromuscular Responses And Ground Reaction Forces Surrounding The Knee, Barbara Mcdowell
Human Movement Sciences & Special Education Theses & Dissertations
Several investigations have noted altered kinetic and neuromuscular landing patterns in adolescent female athletes following various plyometrics programs. The purpose of this study was to investigate the effects of a time-limited plyometrics training program on neuromuscular responses and peak vertical ground reaction force (PVGRF) in Division I collegiate soccer players. Sixteen (8 male, age=l9.38 ± 1.4 yrs, ht= 178.44 ± 8.99 cm, mass =80.38 ± 8.37 kg; 8 female, age=19.75 ± 0.71 yrs, ht=163.83 ± 4.30 cm, mass =62.13 ± 6.29 kg) athletes completed the testing protocol and plyometric training. Seven (3 male, average age=22.00 ± 1.00 yrs, average height=171.88 …
Effects Of Emphysema And Chronic Hypoxemia On Skeletal Muscle Oxygen Supply And Demand, John D. Lowman Jr.
Effects Of Emphysema And Chronic Hypoxemia On Skeletal Muscle Oxygen Supply And Demand, John D. Lowman Jr.
Theses and Dissertations
Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is a condition in which peripheral skeletal muscle undergoes myopathic changes which impair muscle function, limit physical performance, and can lead to significant disability. While the etiology of the dysfunction is unknown, this study was conducted to test the hypothesis that chronic hypoxemia leads to alterations in oxygen transport and muscle function. A primary objective was to validate elastase-induced emphysema in rats as an animal model of skeletal muscle dysfunction in COPD.Arterial blood gases were used to determine the severity of hypoxemia and sodium dodecyl sulfate- polyacrylamide gel electrophoresis was used …