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Regulation Of Ca2+-Activated K+ Channel: Changes With Development, Mike T. Lin
Regulation Of Ca2+-Activated K+ Channel: Changes With Development, Mike T. Lin
Loma Linda University Electronic Theses, Dissertations & Projects
In ovine middle cerebral arteries, it has been shown that the [Ca2+]i change in response to iberiotoxin, a selective BK channel blocker, is significantly different between adult and fetal VSMCs. Our study of basilar VSMCs in whole-cell preparations showed that the total outward current density of fetal myocytes (57.9 ± 6.7 pA/pF) was greater than that of the adult (37.9 ±1.8 pA/pF). This increase in outward current density is contributed by an increase in BK channel current density in fetal myocytes. Excised, inside-out preparations showed that the unitary conductance, as well as the BK channel expression, did …