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Regulation Of Micrornas By 17Β-Estradiol In The Aging Female Brain, Yathindar Satya Giffin-Rao
Regulation Of Micrornas By 17Β-Estradiol In The Aging Female Brain, Yathindar Satya Giffin-Rao
Dissertations
Hormone Therapy (HT) is used to increase the 17β-estradiol (E2) levels in women who are going through the menopausal transition to alleviate the negative symptoms associated with menopause and decrease the risk of chronic diseases. Clinical and basic science research had previously shown that HT provided protection from cognitive decline and reduced the risk of dementia. However the Women's Health Initiative (WHI) clinical trial demonstrated that HT had no beneficial effects for cognitive decline and, in some cases increased the risk of dementia in post-menopausal women. However, further analysis of WHI data showed that when HT was given to women …