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Investigating Anatomical And Molecular Aspects Of Proprioceptive Sensory Neuron Diversity Using A Transgenic Mouse Model, Martha Jean Sonner
Investigating Anatomical And Molecular Aspects Of Proprioceptive Sensory Neuron Diversity Using A Transgenic Mouse Model, Martha Jean Sonner
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Muscle spindles (MS) and Golgi tendon organs (GTOs) are encapsulated, stretch-activated sensory receptors housed within skeletal muscles, yet their functional contributions to proprioceptive monitoring of limb movements are quite different. For example, MS are responsible for detecting stretch of muscle fibers, and GTOs provide feedback regarding muscle tension during contraction. Peripheral axons extending from proprioceptive sensory neurons (PSNs) in the dorsal root ganglia supply MS and GTOs. MS are innervated by Group Ia and II sensory fiber endings, while GTOs are innervated by a single Group Ib sensory fiber. The developmental processes guiding axons from PSNs to their targets and …