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Quantification Of Brain-Region Specific Alterations In Insulin-Like Growth Factor-1 Expression During Developmental Hypothyroidism, Cari Lee Graber-Feesl
Quantification Of Brain-Region Specific Alterations In Insulin-Like Growth Factor-1 Expression During Developmental Hypothyroidism, Cari Lee Graber-Feesl
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Insufficient thyroid hormone (TH) during development results in permanent neurological deficits. These deficits are the result of perturbed TH-mediated brain development. Interestingly, insufficient insulin-like growth factor 1 (Igf-1) during development results in neurological deficits that are similar to those reported for developmental hypothyroidism. This observation suggests that deficits associated with low TH during development may be the result of altered Igf-1 expression in the developing brain. To test this, timed-pregnant mice were treated with thyroid gland inhibitors from gestational day 16 (GD16) until postnatal day 21 (P21) to induce a hypothyroid state. A parallel set of untreated timed-pregnant mice were …