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Physiology

Western University

2017

Concussion

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Impaired Dynamic Cerebrovascular Autoregulation In Adolescent Concussion, Marcy Erin Moir Apr 2017

Impaired Dynamic Cerebrovascular Autoregulation In Adolescent Concussion, Marcy Erin Moir

Electronic Thesis and Dissertation Repository

Although cerebrovascular impairments are believed to contribute to concussion symptoms, little information exists regarding brain vasomotor control in adolescent concussion, particularly during changes in arterial blood pressure (ABP). This research tested the hypothesis that adolescent concussion is marked by impaired dynamic cerebral autoregulation (dCA). Thirty concussed adolescents and thirty healthy controls completed two sit-to-stand trials. Cerebral blood flow velocity and ABP were measured continuously. Cerebrovascular resistance (CVR) was calculated and the rate of drop in CVR relative to the change in ABP provided the rate of regulation (RoR). The concussed adolescents were followed through rehabilitation for up to 12-weeks. At …