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The Role Of Glycogen Synthase Kinase 3 Beta In Skeletal Development, J. Ryan Gillespie
The Role Of Glycogen Synthase Kinase 3 Beta In Skeletal Development, J. Ryan Gillespie
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Glycogen Synthase Kinase 3 beta (GSK-3b) is an important node of regulation in many cellular signaling pathways including insulin and Wnt. Previous work has shown that ubiquitous deletion of GSK-3b is lethal and causes various skeletal abnormalities, but it is not known whether these defects are skeleton-intrinsic. A second GSK-3 protein which shares almost complete homology, GSK-3a, has been shown to have completely overlapping roles with the b form in some cases and independent functions in other cases. Therefore examination of the role of GSK-3b in skeletal development is very poignant.
To examine the role of GSK-3b in skeletal development …