Life Sciences Commons^™

What Is The Number Needed To Treat When Exercise Training Heart Failure Patients?, Neil Smart

Neil Smart

Debate exists on the number needed to treat (NNT) to prevent one mortality with exercise training in heart failure patients. The primary aim of this work was to conduct a sensitivity analysis, removing outlying mortality data from a published meta-analysis of exercise training in heart failure patients. A sensitivity analysis was conducted by removing data from one randomized controlled trial that reported particularly high mortality rates and may be considered a data outlier. Annualized NNTs were subsequently calculated for mortality data from a meta-analysis of exercise training in heart failure patients. Sensitivity analysis showed that the mortality benefit reported by …

Stem Cells And Germ Cells: Microrna And Gene Expression Signatures, Paul Dyce, Derek Toms, Julang Li

Paul W. Dyce

The study of primordial germ cell development in vivo is hampered by their low numbers and inaccessibility. Recent research has shown the ability of embryonic and adult stem cells to differentiate into primordial germ cells and more mature gametes and this generation of germ cells in vitro may be an attractive model for their study. One of the biggest challenges facing in vitro differentiation of stem cells into primordial germ cells is the lack of markers to clearly distinguish the two. As both cell types originate early in embryonic development they share many pluripotent markers such as OCT4, VASA, FRAGILIS, …

Neuro-Muscular Differentiation Of Adult Porcine Skin Derived Stem Cell-Like Cells, Dominik Lermen, Erwin Gorjup, Paul Dyce, Hagen Von Briesen, Paul Müller

Paul W. Dyce

Background Due to the genetic relationship to humans, porcine stem cells are a very important model system to investigate cell differentiation, associated cell signaling pathways, and cell fate. Porcine skin derived stem cells have been isolated from mid-gestation porcine fetus recently. To our knowledge, stem cells from the skin of the adult porcine organism have not been isolated until now. Hence, to our knowledge, we here describe the isolation, expansion, characterization and differentiation of multipotent porcine skin derived stem cell-like cells (pSSCs) from the adult porcine organism for the first time.

Methodology/Principal Findings pSSCs had a spindle shaped morphology similar …

Pharmacology Supplement, Ahmed Mustafa, Ellioott Blumenthal

Ahmed Mustafa Dr.

No abstract provided.

Research Review: Fun Or Fitness?, Mike Climstein

Mike Climstein

No abstract provided.

Research Review: Mixed-Method Cooling In The Heat?, Michael Climstein

Mike Climstein

No abstract provided.

Research Review: Well Don’T Just Stand There!, Mike Climstein

Mike Climstein

No abstract provided.