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Physiology

Selected Works

2003

Articles 1 - 4 of 4

Full-Text Articles in Life Sciences

Epilepsy-Associated Dysfunction In The Voltage-Gated Neuronal Sodium Channel Scn1a, Christoph Lossin, T. Rhodes, R. Desai, C. Vanoye, S. Caniciu, O. Devinsky, A. George Dec 2003

Epilepsy-Associated Dysfunction In The Voltage-Gated Neuronal Sodium Channel Scn1a, Christoph Lossin, T. Rhodes, R. Desai, C. Vanoye, S. Caniciu, O. Devinsky, A. George

Christoph Lossin, Ph.D.

Mutations in SCN1A, the gene encoding the brain voltage-gated sodium channel subunit (Nav1.1) are associated with at least two forms of epilepsy, generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy (SMEI). We examined the functional properties of four GEFS+ alleles and one SMEI allele using whole-cell patch-clamp analysis of heterologously expressed recombinant human SCN1A. One previously reported GEFS+ mutation (I1656M) and an additional novel allele (R1657C), both affecting residues in a voltage-sensing S4 segment, exhibited a similar depolarizing shift in the voltage dependence of activation. Additionally, R1657C showed a 50% reduction in current density and …

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A Model For Shear Stress Sensing And Transmission In Vascular Endothelial Cells, Borbala Mazzag, John S. Tamaresis, Abdul Barakat May 2003

A Model For Shear Stress Sensing And Transmission In Vascular Endothelial Cells, Borbala Mazzag, John S. Tamaresis, Abdul Barakat

Borbala Mazzag

 Arterial endothelial cell (EC) responsiveness to flow is essential for normal vascular function and plays a role in the development of atherosclerosis. EC flow responses may involve sensing of the mechanical stimulus at the cell surface with subsequent transmission via cytoskeleton to intracellular transduction sites. We had previously modeled flow-induced deformation of EC-surface flow sensors represented as viscoelastic materials with standard linear solid behavior (Kelvin bodies). In the present article, we extend the analysis to arbitrary networks of viscoelastic structures connected in series and/or parallel. Application of the model to a system of two Kelvin bodies in parallel reveals that …

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Iodinated Feed Reduces Stress In Steelhead Trout., Ahmed Mustafa Dec 2002

Iodinated Feed Reduces Stress In Steelhead Trout., Ahmed Mustafa

Ahmed Mustafa Dr.

No abstract provided.

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Identification Of Asteroid Genera With Species Capable Of Larval Cloning, K. E. Knott, E. J. Balser, William Jaeckle Dec 2002

Identification Of Asteroid Genera With Species Capable Of Larval Cloning, K. E. Knott, E. J. Balser, William Jaeckle

William Jaeckle

Asexual reproduction in larvae, larval cloning, is a recently recognized component of the complex life histories of asteroids. We compare DNA sequences of mitochondrial tRNA genes (Ala, Leu, Asn, Pro and Gln) from larvae in the process of cloning collected in the field with sequences from adults of known species in order to identify asteroid taxa capable of cloning. Neighbor-joining analysis identified four distinct groups of larvae, each having no, or very little, sequence divergence (p distances ranging from 0.00000 to 0.02589); thus, we conclude that each larval group most likely represents a single species. These field-collected larvae cannot be …

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