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Physiology

Selected Works

1993

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei Sep 1993

Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei

Amy Sprenkle

The protease, a-thrombin (aTh), affects myocardial cell contractility, a feature common among agents that induce hypertrophy. However, it is not known whether cardiac myocytes possess aTh receptors (aTh-R), or if long term treatment with aTh can enhance growth and gene expression. In the present study primary neonatal rat ventricular myocytes expressed a 3.6-kilobase mRNA species that hybridized with a rat aTh-R-specific probe. After 48 h, aTh induced hypertrophy, sarcomeric organization, and enhanced atrial natriuretic factor (ANF) expression, all of which were blocked by the aTh-selective protease inhibitor, D-Phe-Pro-Argchloromethyl ketone. The aTh-R agonist peptide, SFLLRNPND, was a potent activator of ANF …

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Ultrastructure Of The Coeloms Of Auricularia Larval (Holothuroidea Echinodermata): Evidence For The Presence Of An Axocoel, E. J. Balser, E. E. Ruppert, William Jaeckle Dec 1992

Ultrastructure Of The Coeloms Of Auricularia Larval (Holothuroidea Echinodermata): Evidence For The Presence Of An Axocoel, E. J. Balser, E. E. Ruppert, William Jaeckle

William Jaeckle

A hallmark feature of echinoderm larvae is the development of the left anterior coelom. This coelom, called the axohydrocoel, consists of the morphologically distinct, but undivided, left axocel and hydrocel. The axocoelic portion forms a duct that opens to the exterior via a pore on the dorsal surface of the animal. Holothuroid larvae are thought to lack an axocoel, but develop an anterior coelom, duct, and pore that are regarded as parts of the hydrocoel. New ultrastructural data, however, show that holothuroid auricularia larvae possess an axocel and hydrocel united together into an axohydrocoel. During development the anterior coelom consists …

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