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Extent Of Cysteine Modification Of Snap-25 In Vitro, Alex Mcgregor Dabell
Extent Of Cysteine Modification Of Snap-25 In Vitro, Alex Mcgregor Dabell
Theses and Dissertations
Exocytosis, the fusion of a vesicle to a cellular membrane, involves a protein named SNAP-25. This protein, containing two alpha helices connected with a linker region, is localized to the cell membrane via palmitic acids attached to the cysteine residues of its linker region in a process called palmitoylation. Are cysteine residues of the SNAP-25 linker region palmitoylated in an ordered manner and to a particular extent? The answer to this question may give insight into the regulated nature of exocytosis. While it is generally accepted that SNAP-25 must be palmitoylated in order to perform its exocytotic functions, the details …