Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
“Seeing” Beyond The Knees: Inflammation In The Eye As A Result Of Mechanical Stress, Michael Goodman, David Kooyman
“Seeing” Beyond The Knees: Inflammation In The Eye As A Result Of Mechanical Stress, Michael Goodman, David Kooyman
Journal of Undergraduate Research
A correlation between Osteoarthritis (OA), affecting over 27 million people in the US [1], and metabolic syndrome (MS), affecting over 340 million people worldwide [2], becomes strikingly important as the search for an effective treatment for OA continues. Increasing evidence has shown that OA is linked to systemic inflammation and MS. With MS comes other substantial comorbidities, including diabetic retinopathy (DR). Ocular inflammation promoted through mechanically induced OA would provide evidence that mechanical stress can be a factor leading to systemic inflammation. Such results would have profound impacts upon the way we view OA as a metabolic disorder, leading to …
Structural Variations In Articular Cartilage Associated With Osteoarthritis., David Kooyman
Structural Variations In Articular Cartilage Associated With Osteoarthritis., David Kooyman
Journal of Undergraduate Research
Thank you for this MEG award. It led to important research performed primarily by undergraduate students in my laboratory. Our work resulted in some molecular pathways leading to OA that can be exploited by pharmacologic intervention. We exceeded our stated goals for the project. Work from this MEG has already resulted in 2 publications (see below; undergraduate students are in yellow). In addition, we have another paper in review at this time and three others that will be submitted within the next 3-4 months. Besides those students listed as co-authors below, other students that participated in the project are Joshua …
Expression Of Htra1 And Tgfb1 In Osteoarthritis, Karl Andersen, Dr. David Kooyman
Expression Of Htra1 And Tgfb1 In Osteoarthritis, Karl Andersen, Dr. David Kooyman
Journal of Undergraduate Research
Osteoarthritis increasingly debilitates and causes discomfiture to millions of people worldwide. Most people over 65 years of age suffer from symptoms of osteoarthritis. There has, up to this point, been effectively no clear understanding of the processes of the body that contribute genetically or mechanically to this severe condition. The result of this lack of knowledge is a general absence of prevention and treatment measures. As of today, treatments consist only of joint replacement and pain reduction measures.
Researching The Effects Of Osteoarthritis As A Systemic Immune Response, Danielle Peterson, Dr. David Kooyman
Researching The Effects Of Osteoarthritis As A Systemic Immune Response, Danielle Peterson, Dr. David Kooyman
Journal of Undergraduate Research
Our bodies are dynamic structures that do not operate as individual compartments, but as a whole. When something goes awry in one specific tissue or organ, specific signals from that diseased area are released affect other tissues. I received an ORCA grant last year to study my hypothesis that degradation of Osteoarthritis (OA) is primarily associated with a systemic immune response to trauma of articular cartilage. In order to verify this hypothesis, a treatment that creates OA in one localized area while other tissues remained undamaged was needed. The OA genetic mutant mice that researchers normally turn to couldn’t be …
Upr Contributes To Osteoarthritis In The Bardet-Biedl Syndrome Mouse Model, David Nolte, Dr. David Kooyman
Upr Contributes To Osteoarthritis In The Bardet-Biedl Syndrome Mouse Model, David Nolte, Dr. David Kooyman
Journal of Undergraduate Research
Osteoarthritis (OA) is the most prevalent form of arthritis, affecting more than 26 million people in the United States1. The condition decreases mobility and causes pain. Furthermore, the spending for medical treatment of osteoarthritis is increasing quickly: Spending doubled from 1994 to 2005. With the increasing age of the U.S. population, prevalence of OA is expected to continue rising1. Thus it is important to find effective treatments to alleviate symptoms and/or prevent osteoarthritis. Recent research has shown that osteoarthritis involves more than just the cartilage of the joint. Synovium and adipose tissue contribute to the breakdown of articular cartilage2. Also, …
Role Of Primary Cilia In Osteoarthritis, David Kooyman
Role Of Primary Cilia In Osteoarthritis, David Kooyman
Journal of Undergraduate Research
Mentoring in my lab in 2012 has led to both tangible and intangible results. The tangible results for this year include two posters presented at an international meeting by undergraduate students, ORCA grants received by two students, international recognition by a team of undergraduate students, two papers published, three papers in preparation to be submitted within 30 days. The intangible results come as students return from interviews to medical and dental schools with stories of how confident they felt talking about their research. They also come in the form of the excitement I see in students when they talk about …