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Full-Text Articles in Life Sciences
The Role Of Stat And The Jak/Stat Pathway In Mediating The Effects Of Interleukin-6 On Star Expression, Janae Strickland
The Role Of Stat And The Jak/Stat Pathway In Mediating The Effects Of Interleukin-6 On Star Expression, Janae Strickland
Theses and Dissertations
Cortisol, a hormone produced by a hormone produced by the adrenal gland, is responsible for many regulatory functions in the body. Cortisol release is mediated by adrenocorticotrophic hormone, or ACTH, through the hypothalamus-pituitary-adrenal or HPA axis. This HPA axis is the major release pathway used during acute stress, during which the levels of ACTH parallel those of cortisol. However, in states of chronic stress, the level of ACTH drops dramatically, while cortisol remains high. This study focuses on the pathway of cortisol release during these chronic stress states, specifically examining the role of IL-6 with respect to STATs and the …