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Osteoblast Oncostatin M Signaling In Modeled Spaceflight, Jacob Goyden
Osteoblast Oncostatin M Signaling In Modeled Spaceflight, Jacob Goyden
Boise State University Theses and Dissertations
Bone deterioration is a challenge in long-term spaceflight with significant connections to terrestrial disuse bone loss. Prolonged unloading and radiation exposure, defining characteristics of space travel, have both been associated with changes in inflammatory signaling via IL-6 class cytokines in bone. While there is also some evidence for perturbed IL-6 class signaling in spaceflight, there has been scant examination of the connections between free fall, radiation, and inflammatory stimuli in bone. Our lab and others have shown that the IL-6 class cytokine oncostatin M (OSM) is an important regulator of bone remodeling. We hypothesize that spaceflight alters osteoblast OSM signaling, …