Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Acute Kidney Injury And Chronic Kidney Disease, Jin Wei
Acute Kidney Injury And Chronic Kidney Disease, Jin Wei
USF Tampa Graduate Theses and Dissertations
Ischemia and reperfusion are natural steps during kidney transplantation, and IRI is considered one of the most important nonspecific factors affecting allograft dysfunction. Transplanted organs experience several episodes of ischemia, in which cold ischemia occurs during allograft storage in preservation solutions.
Even though cold ischemia has been studied extensively, all of the studies have been carried out in vitro and ex vivo models. There is no in vivo model available to examine renal IRI induced solely by cold ischemia.
In the present study, we developed an in vivo mouse model to study renal IRI induced exclusively by cold ischemia through …