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Physical Sciences and Mathematics

Research on Capitol Hill

2018

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Transplanting A Bacterial Immune System: Determining The Function Of A Novel Crispr System, Riannon Smith, Melena Garrett Jan 2018

Transplanting A Bacterial Immune System: Determining The Function Of A Novel Crispr System, Riannon Smith, Melena Garrett

Research on Capitol Hill

CRISPR (Clusters of Regularly Interspaced Short Palindromic Repeats) loci and cas (CRISPR-associated) genes provide adaptive immunity (see panel below) in bacteria and have recently been repurposed for genome editing.

Systems are structurally and functionally diverse.

  • 2 classes, 6 types, 33 subtypes
  • Very few have been studied experimentally
  • None of the Type IV systems have been characterized

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