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H69, NMR, pseudouridine, ribosome, RNA-protein interaction, S20
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"Fine-Tuning" Of Ribosomal Structure And Functions By Pseudouridylation And Rna-Protein Interactions, Jun Jiang
"Fine-Tuning" Of Ribosomal Structure And Functions By Pseudouridylation And Rna-Protein Interactions, Jun Jiang
Wayne State University Dissertations
ABSTRACT
"Fine-tuning" of ribosomal structure and functions by pseudouridylation and RNA-protein interactions
by
JUN JIANG
AUGUST 2012
Advisor: Prof. John SantaLucia Jr.
Major: Chemistry (Biochemistry)
Degree: Doctor of Philosophy
Ribosomal structure and functions appear to be "fine-tuned" by pseudouridylation and RNA-protein interactions. Pseudouridylation may promote base stacking interactions by mediating the base stacking between residues on both sides. In the RNA duplex region, this enhanced stacking interaction contributes to stabilization of duplex folding. In the loop region, enhanced stacking in one structural motif may destabilize the conformation of adjacent structural residues. This hypothesis is supported by both UV-melting experiments, where …