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Acth4 -10, Substance P, And Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy In Goldfish, Rosana Mattioli, Joseph P. Huston, Richard E. Spieler
Acth4 -10, Substance P, And Dizolcipine (Mk-801) Accelerate Functional Recovery After Hemilabyrinthectomy In Goldfish, Rosana Mattioli, Joseph P. Huston, Richard E. Spieler
Marine & Environmental Sciences Faculty Articles
In this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over time. The behavioral effects of two neuropeptides were tested–namely, of substance P and ACTH4-10, both of which are known to promote functional recovery in several other lesion models. Furthermore, the effect of MK- 801, an antagonist of the glutamatergic NMDAreceptor subtype, was tested because this substance has also been shown to exert a neuroprotective effect. After lesion …