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Full-Text Articles in Life Sciences
The Role Of Secretory Phospholipase A2 Group Iia In Obesity And Metabolism, Michael S. Kuefner
The Role Of Secretory Phospholipase A2 Group Iia In Obesity And Metabolism, Michael S. Kuefner
Theses and Dissertations (ETD)
Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases previously implicated in inflammation, atherogenesis, and antibacterial actions. These enzymes hydrolyze glycerophospholipids at the sn-2 position releasing lysophospholipids and fatty acids. Though studies have shown PLA2G2A is pro-inflammatory and promotes atherosclerosis, no research has analyzed the role of this enzyme in obesity and metabolism. Studies in the past 5-10 years utilizing various knock- out or over-expression mouse models have analyzed the role of different secretory phospholipase A2s (sPLA2) in metabolic diseases. From these studies, it is known that at least seven of the 11 sPLA2 …
Are Health Problems In Adulthood Linked To Our Experiences In The Womb? An Epigenetic Approach, Simone Tendler
Are Health Problems In Adulthood Linked To Our Experiences In The Womb? An Epigenetic Approach, Simone Tendler
The Science Journal of the Lander College of Arts and Sciences
The origins of adult disease have been a prime topic for research, as deciphering causes can lead to strategies for preventions and cures. There has been recent intrigue focused on the environment in the womb. Records from England and Wales in 1911 show that those who suffered from cardiovascular disease were geographically correlated with regions high in infant mortality in the past, seventy years before the study. When looking into the cause of the neonatal death rates, low birth weight, poor maternal health, and high maternal death rates during childbirth were clearly associated. Barker inferred that there is much happening …
The Relationship Between Pcos And Obesity: Which Comes First?, Sara L. Rosenberg
The Relationship Between Pcos And Obesity: Which Comes First?, Sara L. Rosenberg
The Science Journal of the Lander College of Arts and Sciences
Polycystic ovary syndrome (PCOS) is recognized as the most common reproductive disorder in women. Obesity is believed to play a central role in the development of PCOS, as many women with this condition are reported to be overweight or obese. A strong correlational relationship exists between PCOS and obesity. This paper examines the relationship between PCOS and obesity in order to determine whether PCOS causes obesity as opposed to obesity causes metabolic changes that lead to PCOS. Analysis was conducted by reviewing and comparing many studies related to the topic. Factors such as insulin resistance, hyperandrogenemia and body fat distribution …