Life Sciences Commons^™

Microbial Characteristics Of An Activated Sludge And Three Commercial Preparations After Exposure To Phenolics, Laurie Gneiding

Theses

The biological characteristics of four microbial mixtures were examined after successive exposure to phenol and 2-chlorophenol at room temperature. One of the microbial mixtures was an activated sludge from the Livingston, NJ municipal wastewater treatment plant. The other three mixtures were commercial preparations sold by Polybac Corp.(Hydrobac), Sybron Corp. (BI-CHEM DC 1006/1007), and General Environmental Sciences(LLMO).

The characteristics examined were relative counts and species of gram negative/gram positive bacteria, yeast and fungi, protozoa, and higher organisms. For the gram negative bacteria and yeasts, culturing techniques and diagnostic tubes were used to determine the predominant species. Biochemical tests were done on …

Acute Effects Of Phenytoin And Thioridazine, Alone And Combination, Upon Water Intake And Body Weight Changes In Rats, Miriana Witzig-Krstic

Masters Theses

Concommitant medication of anticonvulsants and psychotropics appears to be predominant among mentally retarded, geriatric, and psychiatric in- and out-patient populations. Despite suggested interaction and toxicity resulting from such combination treatment, substantial data remains unavailable. This study was designed to explore effects of dual treatment of thioridazine

Toxicological Studies On Aquatic Contaminants Originating From Coal Production And Utilization: The Induction Of Tolerance To Silver In Laboratory Populations Of Fish And The Chronic Toxicity Of Nickel To Fish Early Life Stages, Wesley J. Birge, Jeffrey A. Black, James F. Hobson, Albert G. Westerman

KWRRI Research Reports

Aquatic toxicity studies were performed on two important coal-derived contaminants, silver and nickel. Silver was investigated with regard to metal-induced tolerance in laboratory populations of the fathead minnow (Pimephales promelas). Fish were exposed to acute silver concentrations following acclimation to sublethal exposures of this metal. Based on median lethal times (LT50), animals which had received 14 days prior exposure to 1.5 and 15 μg Ag/L were three to four times more resistant to silver than were previously unexposed organisms. This metal-induced resistance was not a sustained response. After organisms which had been acclimated to 15 μg/L had been transferred to …

The Effects Of Tri-O-Cresyl Phosphate On 2',3'-Cyclicnucleotide-3'-Phosphohydrolase Activity In Neural And Non-Neural Tissue Of The Rat, Mark K. Schlager

Chemistry & Biochemistry Theses & Dissertations

A total of 44 Long-Evans rats received 5.7 g/kg tri-O-cresyl phosphate (TOCP) orally every 3 days for 6 days. A second group of 13 rats received 4.6 g/kg orally every 3 days for 6 days. Animals were administered atropine sulfate (10 mg/kg) intraperitoneally every 6 hours or as needed to alleviate cholinergic symptoms. Ten control animals were given corn oil orally. Eight rats (18%) survived the 5.7 g/kg dose regimen and 5 rats (38%) survived the 4.6 g/kg dose regimen. Surviving rats were killed at 30-33 days post-dose. Signs of delayed neuropathy included ataxia and motor impairment.

The CNP activity …

The Effects Of Maternal Administration Of Methadone On Beta-Endorphin Content In The Brain And Pituitary Of The Rat Progeny, Randall L. Braun

Loma Linda University Electronic Theses, Dissertations & Projects

Methadone is often used in the maintenance and detoxification of opioid-dependent pregnant women. This use of methadone during pregnancy is known to be associated with teratogenic effects observed in the progeny. The present study is an attempt to gain insight into possible pathophysiologic mechanism(s) responsible for these teratogenic effects: specifically, a relationship between maternal methadone administration and the content of the endogenous opioid peptide, beta-endorphin, in the brain and pituitary of the rat progeny.

In brief, nulliparous mature female Sprague-Dawley rats received daily injections (5 mg./kg.) of methadone hydrochloride (methadone-treated) or a similar volume of physiological saline (controls), treatment started …

Analysis Of Selected Volatile Organic Substances Associated With Residential Kerosene Heater Use And The Health Implications, Catherine Coombs Bobenhausen

Theses

Volatile organic species (aliphatic hydrocarbons from hexane to dodecane, cyclohexane and aromatic species including benzene, toluene, ethyl benzene, m,p, and o—xylenes, nitrobenzene, styrene and naphthalene) associated with residential kerosene heater emissions were measured at two sites. One was a small room having a total volume of 23.66 cubic meters and an air change rate of 2.71 air changes per hour, and the other, a living/dining room area having a combined volume of 79.30 cubic meters and an estimated air change rate of .7 air changes per hour. The analytical procedure involved collection of a series of air samples in stainless …

Investigations Into Rates And Mechanisms Of Mercury Depuration In The Killifish, Fundulus Heteroclitus, Joanne A. Korpanty

Theses

Metallothionein (MT) and glutathione (GSH) have been shown in mammalian research to play a role in the sequestration and depuration of mercury. The sulfhydryl groups on both these peptides have a strong affinity for mercury, MT for Hg²⁺ and GSH for CH₃Hg⁺. In this study, killifish (Fundulus heteroclitus) were force-fed one piece of squid laced with labelled mercuric nitrate to give a final food concentration of 20 ppm ²⁰³Hg²⁺ and 0.03 -0.05 µg g-1 Hg²⁺ total dose. Most of the mercury, 84.1 ± 12.1% (mean ± standard deviation), is depurated within the …

Acrylamide Effects On Nerve Terminal Enzymes, Christopher S. E. Marlowe

Theses

Acrylamide causes a peripehral neuropathy. The biochemical mechanism by which it does so is the subject of intense investigation. One of the principal hypotheses for this mechanism centers on acrylamide's ability to inhibit glycolysis. This study examines the effects of in vivo exposure to acrylamide on the enzymes of the nerve terminal particle, the synaptosome.

A method for measuring glycolytic enzyme inhibition in the synaptosome was developed. Acrylamide (500 mg/kg) was administered to rats intraperitoneally. Synaptosomes were prepared by the method of Dodd et al, and lysed by sonication. GAPDH activity and NSE concentration were measured. GAPDH inhibition measured in …

Sunlight And Plants, Some Pursuits In Physiological Ecology, Martyn M. Caldwell

Faculty Honor Lectures

A physiological ecologist, as the name suggests, focuses on the interface between plant physiology and the ecology of individual organisms. Yet, one in this field should know something about disciplines ranging from physiology, or in the case of the subject of this lecture, even photochemistry, to the study of entire ecosystems.

Effects Of 3, 5, 6-Trichloro-2-Pyridinol On Thyroid Function, Charles Franklin Luke

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

3,5,6-trichloro-2-pyridinol, when administered in the diet, increases the feed efficiency (the ratio of weight gain to feed consumed) in various species of domestic animals and also appears to be retained in the liver at low concentrations, possibly by binding to a specific macromolecule. Because of its structural similarities to the outer ring of the thyroid hormones, trichloropyridinol and three structural analogs (2,4,5-trichlorophenol, 4-bromo-2,5-dichlorophenol, or 4-iodo-2,5-dichlorophenol) were tested for ability to compete in vitro with 3,5,3'-triiodothyronine (T₃) for nuclear receptors specific for the thyroid hormones. All four of the halogenated compounds were found to be weakly competitive for the …

Natural Killer Cell Activity And Beta-Endorphin In The Mink (Mustela Vison) And The In Vitro Effect Of Beta-Endorphin In Immunologic Assays, Nancy Cathleen Pace

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to investigate natural killer cell activity and the possible role of beta- endorphin in a natural model of autoimmune orchitis, the dark mink.

An assay was developed to study natural killer cell activity in the mink and base-line levels of activity in this specie were determined. Natural killer cell activity was assessed in fertile mutation mink, primary infertile dark mink and secondary infertile Utah dark mink with autoimmune orchitis. The study included three sampling times: November, March and April. Natural killer cell activity was significantly lower in mink studied in April than it was …

Synthesis Of 6-Aminopenicillanic Acid-Protein Conjugates For Development Of Enzyme Immunoassay For B-Lactam Antibiotics, Alice Ann Heth

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

An enzyme immunoassay specific for several β-lactam antibiotics rather than individual antibiotics was investigated. The goal to develop an enzyme immunoassay for analysis of a whole class of compounds at one time is different than the goal of most enzyme immunoassays which desire specificity for drugs or hormone levels. Detection of the presence of all β-lactam antibiotics is wanted and identification of specific antibiotics is not needed.

6-Aminopenicillanic acid, the common structural moiety of β-lactam antibiotics was used tin this investigation. Methods of preparation of 6-aminopencillanic acid conjugates and antibodies needed for enzyme immunoassays have been developed. 6-Aminopenicillanic acid was …

Lead Poisoning Of Sandhill Cranes (Grus Canadensis), R. M. Windingstad, S. M. Kerr, L. N. Locke, J. J. Hurt

Papers in Ornithology

Two wild and two captive sandhill cranes (Grus canadensis) were diagnosed by National Wildlife Health Laboratory personnel as having died from lead toxicity. Ingestion of lead fishing weights by the wild cranes and of unspent .22 caliber shell cartidges by the captive cranes were responsible for these deaths. One crane force-fed lead pellets showed an increase of blood lead levels from 0.77 ppm to 23.8 ppm (wet weight) just before its death 15 days following exposure. Liver lead concentrations of sandhill cranes dying of causes other than lead toxicity are presented.

How Rabbit Poisoning Methods Work, S H. Wheeler

Journal of the Department of Agriculture, Western Australia, Series 4

While the "rabbit plauges" of the past are a distant memory for most farmers, rabbit numbers must still be controlled in many parts of Western Australia. Rabit control techniques rely heavily on poisoning, which given the right conditions can kill a high percentage of rabbits at risk.

Recent research by the Agricultural Protection Board has been aimed at determining how different poisons, baits and poisoning methods work. By knowing in detail how each method works and what influences its results, we can choose the best control method for a particular place and time, avoid costly failures, and increase the effectiveness …

Evaluation Of Carbon-14 Uptake Algal Toxicity Assay And Its Application In Field Assessment Of Tributyltin Chloride And Chlorinated Sewage Toxicities, Soon Lin Ho

Dissertations, Theses, and Masters Projects

No abstract provided.

1080 : A Selective Poison For Pests, D R. King

Journal of the Department of Agriculture, Western Australia, Series 4

Since the 1960s, the control programmes for rabbits and dingoes in Western Australia have relied heavily on the use of sodium monofluoroacetate, more commonly known as compound 1080. Large quantaties are used each year as it is a valuable substance for the control of vertebrate pests.

Once in the animal's body 1080 is converted to fluorocitrate, a poison which is highly toxic to most mammals. Fluorocitrate blocks the Krebs cycle, a fundamental pathway of energy exchange in animals and plants. The animal dies as a result of damage to the heart, or to the brain and central nervous system, or …

บทบาทของการตรวจสอบยาเบื้องต้น ในระบบการกระจายยาสำเร็จรูป(Basic Tests And Their Role In The Distribution Chain Of Pharmaceutical Preparations), ศิรินารถ วาสนะวัฒน, ภักดี โพธิศิริ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The Estimation Of Protein Concentration Of Tissue Extracts By The Method Of Coomassie Dye-Binding, Biuret And Ultraviolet Absorption : Comparision With The Lowry Method.(การวิเคราะปริมาณโปรตีนของสาร..., W. Chaidee, K. Akraksasilapachai, S. Pongsamart

The Thai Journal of Pharmaceutical Sciences

The protein concentrations of crude extracts and partially purified protein extracts from mammalian tissues were estimated by the method of Lowry in order to compare with other methods of protein assay including the method of Bradford ; the formation of ...

วิทยาการก้าวหน้า, สุนันท์ หงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ฤทธิ์ไม่พึงประสงค์ที่เกิดจากยา ตอนที่ 7 ใน 10 ตอน, สุกัญญา นิมมานนิตย์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

แอลกอฮอล์ และ วิตามิน บี, อรอนงค์ กังสดาลอำไพ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

“ยาที่ต้องระวัง" (Antispasmodic), ดร. สุกัญญา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ย่อยข่าวยา, สุนันท์ หงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ตลาดยา U.S.A. : ชื่อการค้า Vs. ชื่อสามัญ., สุนันท์ หงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Effect Of Ph, Surfactants And Preservatives On Antifungal Activity Of Tea Seed Cake Extract.(ผลของพีเอช สารลดแรงตึงผิว และสารกันเสีย ต่อฤทธิ์การต้าน..., Siriporn Tongwichai, Piyaratana Tosukhovong, Prapa Laohapaibul, Sudhe Vekavayanondha, Sukanya Nimmannit

The Thai Journal of Pharmaceutical Sciences

Partially purified drug (TK) isolated from Tea Seed Cake showed antifungal activity against Trichophyton mentagrophytes and Saccharomyces cerevisiae. A 2 % aqueous solution of the drug showed 90 % of maximal activity when tested in vitro. The pH of 1 % T...

ประมวลบทคัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Pharmacokinetics Of Theophylline Injections In Rabbits, U. Suvanakoot

The Thai Journal of Pharmaceutical Sciences

Pharmacokinetics of the theophylline injections were studied in four New Zealand rabbits, weighing 3 to 4 kg. Each rabbit received theophylline, 200 mg. as a continuous (10-m inute) intravenous infusion. The pharmacokinetics of theophylline were describe...

วิทยาการก้าวหน้า, สุนันท์ หงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, อรอนงค์ กังสดาลอำไพ, นุชรี เบญจานุวัตรา, สุกัญญา นิมมานนิตย์, สุนันท์ หงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Metabolism And Disea Ses In Traditional Medicine, Prachote Plengvidhya

The Thai Journal of Pharmaceutical Sciences

No abstract provided.