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Microcystin Exposure And Liver Injury Outcomes In Nafld, Muayad Albadrani
Microcystin Exposure And Liver Injury Outcomes In Nafld, Muayad Albadrani
Theses and Dissertations
Non-alcoholic fatty liver disease (NAFLD) is an emerging worldwide pandemic which is highly prevalent among obese individuals including children and adults. In a NAFLD condition, exposure to environmental contaminants or toxins can act as a second/ multiple hit, which leads to the progression of simple steatosis to NASH and ultimately may result in liver cirrhosis. With climate change today, elevated levels of microcystins are an emerging problem in fresh water bodies, which are a source of drinking water. Individuals are therefore at risk of exposure to microcystin through consuming contaminated water. In the progression of NAFLD from one clinical stage …
A Compromised Liver Alters Pcb Toxicity And Nutrient Metabolism, Jazmyne D. L. Barney
A Compromised Liver Alters Pcb Toxicity And Nutrient Metabolism, Jazmyne D. L. Barney
Theses and Dissertations--Toxicology and Cancer Biology
Environmental contamination is a public health concern. In particular persistent organic pollutants like Polychlorinated Biphenyls (PCBs) have been associated with multiple chronic inflammatory diseases, including non-alcoholic fatty liver disease (NAFLD). NAFLD prevalence has steadily increased and is expected to continue to rise with an estimated 25% of the world’s population and 80-100 million people affected in the United States alone. Importantly, the liver is the primary site for endobiotic and xenobiotic metabolism, hence its proper function is critical for the body’s response to innate and extrinsic molecules. One way to combat the deleterious effects of PCB toxicity and fatty liver …