Life Sciences Commons^™

Hepatotoxic And Nephrotoxic Effects Of Chronic Exposure To Vernonia Cinerea Crude Extract On Wistar Rats, Thularath Toommakorn, Sajee Waramit, Patchara Danaisawadi, Kantimanee Pradermwong

The Thai Journal of Pharmaceutical Sciences

Vernonia cinerea L. (VC) has been used for smoking cessation and decreased appetite in Thailand. However, the safety of this plant concerning long-term consumption has never been reported. A 6-month toxicity study of VC water crude extract (VCWE) was performed in both genders of Wistar rats at doses of 15, 150, and 1500 mg/kg body weight/day orally. Recovery group received 1500 mg/kg for 6 months and then extended for 14 days without the extract. It was found that the males could not tolerate the highest dose of VCWE. There was no effect on bodyweight, relative organ weight, nor hematological parameters …

Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib

The Thai Journal of Pharmaceutical Sciences

Introduction: Kratom (Mitragyna speciosa Korth) is currently used as an alternative for the self-treatment of pain and management of opioid dependence and withdrawal. Due to the opioid-like effect of the plant’s active alkaloid, mitragynine (MG), the evaluation of its ability to maintain self-administration in animal models of opioid dependence appears to be great significance. Objectives: Here, the ability of MG to cross-substitute to the reinforcing effects of the synthetic narcotic fentanyl is investigated. Methods: Rats with implanted catheters were allowed to self-administer fentanyl (2.0 μg/kg/infusion) on a fixed-ratio 1 of schedule of reinforcement. Results: A significant increase in lever pressing …

Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib

The Thai Journal of Pharmaceutical Sciences

The plant Mitragyna speciosa Korth. is receiving increased attention as a therapeutic substitution for opioid use disorder (OUD). The active alkaloids constituents of the plant, particularly mitragynine and 7-hydroxymitragynine, have been shown to modulate opioid receptors, acting as agonists at mu-opioid receptors. Given this pharmacology, several studies have examined the abuse and dependence potential of M. speciosa and its alkaloids in various animal models of dependence. In addition to action on opioid receptors, the Mitragyna alkaloids also appear to exert diverse activities at other receptors in the central nervous system which may explain the complex pharmacological profile of these alkaloids. …

Acute Oral Toxicity Test Of Quercusinfectoria G. Olivier Extract In Rats, Tuanta Sematong, Sirinan Thubthimthed, Sareeya Reungpathanapong, Sarunya Laovitthayanggoon, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Acute Oral Toxicity Test Of Anaxagorea Luzonensis A. Grey And Ziziphus Attopensis Pierre Extract In Rats, Phanukit Kunhachan, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Acute Oral Toxicity Test Of Muntingia Calabura L. Extract In Rats, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Phanukit Kunhachan, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Anticoagulants For The Control Of Rats And Mice, C D. Gooding

Journal of the Department of Agriculture, Western Australia, Series 4

LATELY there have been many requests for information on suitable poisons to use in baiting rats and mice.

Most enquirers have stated that they "tried a certain brand of bait" and found that the rats only "ate it up and kept coming back for more."

This article on Warfarin—as a rat and mouse poison—is presented to clear up some of the problems of rodent poisoning.

Rats And Mice And Their Control, C D. Gooding, J. L. Long

Journal of the Department of Agriculture, Western Australia, Series 4

BEFORE colonisation by the white man, Australia contained over 50 species of rats and mice.

Although several of these native species have been known to breed to plague proportions they are normally slower breeders than the introduced species.

Once settlement had been established on our shores it was only a matter of time before the introduction of more of these pests, occurred probably from the British Isles.