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Pharmacology, Toxicology and Environmental Health

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2016

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Articles 1 - 30 of 47

Full-Text Articles in Life Sciences

Implementation Of Universal Hplc Analysis For Counterfeit Medication: A Partnership Of Purdue University And The Kilimanjaro School Of Pharmacy, Jordyn Mccord, Michael Mavity, David Wintczak Oct 2016

Implementation Of Universal Hplc Analysis For Counterfeit Medication: A Partnership Of Purdue University And The Kilimanjaro School Of Pharmacy, Jordyn Mccord, Michael Mavity, David Wintczak

Purdue Journal of Service-Learning and International Engagement

Jordyn McCord and Michael Mavity are 2016 graduates of both biological engineering and pharmaceutical sciences. David Wintczak is a third-year pharmacy doctoral candidate. Here, in their second article published in PJSL, they describe a weeklong study abroad course at the Kilimanjaro School of Pharmacy in Tanzania, designed to engage students in the implementation of methods for detecting counterfeit medications.


How Do The Social Benefits And Costs Of The Patent System Stack Up In Pharmaceuticals?, Daniel J. Gifford Oct 2016

How Do The Social Benefits And Costs Of The Patent System Stack Up In Pharmaceuticals?, Daniel J. Gifford

Journal of Intellectual Property Law

This paper explores the workings of the patent system in the context of the generation of new pharmaceutical products. First it identifies the relevant characteristics of the patent system and its relation to the market. The paper concedes that, in general, the patent system is probably the best way of generating new technology, in substantial part because that system uses the market to provide both incentives and rewards. The paper also identifies downsides of this patent/market system: deadweight loss and the unresponsiveness of that patent/market system to the needs of the poor. The paper then explores the social costs and …


Water Quality And Fecal Coliform Levels In Georgia Oxbow Lakes Relative To Connectivity With The Savannah River, Carly B. Williams, John E. Weinstein, Claudia L. Rocha May 2016

Water Quality And Fecal Coliform Levels In Georgia Oxbow Lakes Relative To Connectivity With The Savannah River, Carly B. Williams, John E. Weinstein, Claudia L. Rocha

Georgia Journal of Science

The state of Georgia has many bodies of water that provide important wildlife habitats as well as recreational opportunities. The objective of the current study was to investigate water quality and fecal coliform levels in oxbow lakes relative to their connectivity to the Savannah River. For most water quality parameters, no differences were observed between the Savannah River and the oxbow lakes. However, pH and turbidity values were lower in the oxbow lakes (both connected and disconnected) relative to the Savannah River. Fecal coliform values between connected oxbow lakes and the Savannah River were similar to each other and significantly …


What You Ignore At Work May Harm You: The Effects Of Light, Design, And Nature, Shelby L. Beutel May 2016

What You Ignore At Work May Harm You: The Effects Of Light, Design, And Nature, Shelby L. Beutel

BU Well

This paper looks into the effects of light, design, and nature on employees by incorporating environmental health and environmental design research into useful suggestions for the employee and the employer. The “fit” between a user and their work space has been elaborated on in recent years, and it has been shown that insufficient lighting can cause poor fit and consequential draining of energy and productivity. In the healthcare setting, medication errors have been linked to the amount of lighting within a hospital and to the variable amount of daylight throughout the year. While there is not a quick and easy …


Influence Of Water Hardness On Accumulation And Effects Of Silver In The Green Alga, Raphidocelis Subcapitata, Aarya Venkat, Adriana L. Amerson, Gretchen K. Bielmyer-Fraser Apr 2016

Influence Of Water Hardness On Accumulation And Effects Of Silver In The Green Alga, Raphidocelis Subcapitata, Aarya Venkat, Adriana L. Amerson, Gretchen K. Bielmyer-Fraser

Georgia Journal of Science

Metal pollution from anthropogenic sources can pose a threat to aquatic systems. Silver is released into the environment from various industrial processes. In excess, silver can accumulate and cause adverse effects in aquatic organisms, particularly those in lower trophic levels, such as phytoplankton. Water chemistry parameters, such as hardness, have been shown to modify toxicity of metals because divalent cations compete with the metal for binding sites on the biological membrane. The objective of this study was to assess population growth and silver accumulation in the green alga, Raphidocelis subcapitata, after silver exposure in waters of varying hardness for 7 …


Xenoestrogens From Household Plastics Bind Estrogen Receptors And Affect Cell Proliferation, Susan G. Hurley, Brett R. Lackey, Patricia L. Tate, Sandra L. Gray Mar 2016

Xenoestrogens From Household Plastics Bind Estrogen Receptors And Affect Cell Proliferation, Susan G. Hurley, Brett R. Lackey, Patricia L. Tate, Sandra L. Gray

Journal of the South Carolina Academy of Science

Xenoestrogens are “foreign” chemicals or compounds that interact with estrogen receptors as either agonists or antagonists to interfere with endocrine system function. Xenoestrogens include phytoestrogens, pesticides, industrial by- products and synthetic estrogens. In this study, consumer plasticware, including baby bottles and food storage containers, were found to release xenoestrogenic compounds that bound to ERα and ERβ and affected cell proliferation.


Thromboxane A2 And Tp Receptors: A Trail Of Research, Well Traveled, Perry V. Halushka Phd, Md Mar 2016

Thromboxane A2 And Tp Receptors: A Trail Of Research, Well Traveled, Perry V. Halushka Phd, Md

Journal of the South Carolina Academy of Science

This article was written is response to a request from the editor-in-chief as a result of my receiving the Governor’s Award in Scientific Awareness. My goal is to provide a glimpse into a 40 plus year research career that was predominately focused on the role of thromboxane A2 and its receptor (TP) in physiologic and pathophysiologic processes in the cardiovascular system. It also enumerates the lessons learned along the way that may lead to a productive research career. Those lessons were; Perseverance, Think out of the box, Challenge the dogma, Take risks, Failure is not a bad thing, Focus, …


The Real Footprint Of Electric Vehicles, And What That Could Mean For Our Future, Krista Brown Jan 2016

The Real Footprint Of Electric Vehicles, And What That Could Mean For Our Future, Krista Brown

Journal of Environmental and Resource Economics at Colby

This paper looks at the impact of electric vehicles on CO2 emissions specifically based on the type of electricity used in each New England state analyzed. The research looks at the question of whether or not emissions will in fact be lowered as electric cars start to take the majority of vehicles used instead of the conventional cars that take up a much larger percent of the motor vehicles used today. Taking into account the use of electricity and how many sources of electricity also release a substantial amount of emissions, we see how valid the public opinion of electric …


The Effect Of Information On Avoidance Behavior And Bicycle Transportation: A Study Of “Spare The Air” And Bay Area Bikeshare, Paige W. Whistler Jan 2016

The Effect Of Information On Avoidance Behavior And Bicycle Transportation: A Study Of “Spare The Air” And Bay Area Bikeshare, Paige W. Whistler

Journal of Environmental and Resource Economics at Colby

This paper seeks to address the effect of “Spare the Air” pollution control alerts in the San Francisco Bay Area in California on the use of Bay Area BikeShare as a form of transportation. By observing the daily alerts on the duration of rides using BikeShare, this paper observes if STA ozone alerts are effective in changing human behavior. The results show that only as a subscriber to the BikeShare program and on an alert day does duration decrease whereas customers regardless of if it is an alert day will ride more often and at longer distances. The results contradict …


Socioeconomic Attributes’ Relationship To Green Commercial Office Buildings, Tianyang Zhou Jan 2016

Socioeconomic Attributes’ Relationship To Green Commercial Office Buildings, Tianyang Zhou

Journal of Environmental and Resource Economics at Colby

This paper examines the relationship between the socioeconomic attributes of a state and its green commercial office space adaptation. I hypothesize that a state with high socioeconomic status will have a high green building adoption. Additionally, the high socioeconomic status states may be more likely to invest in green commercial buildings with higher LEED certification levels, and various types of LEED commericial office projects are affected by the socoeconomic attributes differently.


Do Peers Get Punished: Stock Market Effect Of Bp Oil Spill On Peers, Yuga Koda Jan 2016

Do Peers Get Punished: Stock Market Effect Of Bp Oil Spill On Peers, Yuga Koda

Journal of Environmental and Resource Economics at Colby

This paper examines the stock market reaction to the British Petroleum oil spill on April 20, 2010. This event study looks at different sectors that may be affected by the oil spill. It finds that different industries do not have significant abnormal returns, with two exceptions. First, utilities companies have a very small positive abnormal return for a short period of time after the incident. Second, when only looking at BP's direct competitors, there is a statistically significant negative abnormal return, implying that BP's competitors are punished for BP's mishap.


Media Effects On Solar Panel Installations Across 20 States, Casey Romeo Jan 2016

Media Effects On Solar Panel Installations Across 20 States, Casey Romeo

Journal of Environmental and Resource Economics at Colby

This paper looks at the relationship between media coverage of solar power and the solar panel installation at a state level. Specifically, it aims to find if more newspaper articles cause more households to adopt solar energy. Use data from 20 states from 2009 to 2014. I find that there is a modest, yet positive and statistically significant relationship between newspaper articles and installations, which suggests that the media does influence the decision to install solar panels. There is possible endogeneity between these two variables. Disentangling this endogeneity is beyond the scope of this research and would be a topic …


Renewable Energy Consumption: Initiatives In Colorado And Washington, Robin K. Doroff Jan 2016

Renewable Energy Consumption: Initiatives In Colorado And Washington, Robin K. Doroff

Journal of Environmental and Resource Economics at Colby

This paper examines the use of policy mechanisms to increase renewable energy consumption within the United States. In order to effectively measure the change of renewable energy consumption, I analyze two initiatives that promote energy consumption from renewable sources and overall increases in energy conservation. Colorado and Washington had approved initiatives in the years 2004 and 2006, respectively. Although the results are not entirely statistically significant, I find that the initiatives lead to increases in total renewable energy consumption and decreases in total energy use.


Stock Market Reactions To The Iarc Announcement Linking Red Meat And Processed Meat To Cancer, Scott B. Lehman Jan 2016

Stock Market Reactions To The Iarc Announcement Linking Red Meat And Processed Meat To Cancer, Scott B. Lehman

Journal of Environmental and Resource Economics at Colby

This study investigates how food companies were affected by the International Agency for Research on Cancer’s report that linked processed meat and red meat consumption to increased risk of cancer. The results indicate that neither fast food companies nor meat producers were greatly affected by the announcement in the days immediately following the release.


Property Value Changes From Public Transportation: How The Greenbush Commuter Line Affected Property Values, Sarah C. Evans Jan 2016

Property Value Changes From Public Transportation: How The Greenbush Commuter Line Affected Property Values, Sarah C. Evans

Journal of Environmental and Resource Economics at Colby

Prior studies have investigated the impact on property values to the proximity of established public transportation stations. Public transportation is thought to increase value of towns and properties, giving residents more options for transportation to and around the city. Both benefits and consequences of public transportation exist, allowing for either a raise or lower of property values in towns with stops. This paper analyzes the Greenbush Commuter line in Massachusetts, seeing if the proximity to the stops has an affect on the property of values in the towns. A difference – in – difference model is used to investigate a …


The Effectiveness Of The Colby College Electricity Competition On Promoting Electricity Conservation To Students, Jeff Vaz Jan 2016

The Effectiveness Of The Colby College Electricity Competition On Promoting Electricity Conservation To Students, Jeff Vaz

Journal of Environmental and Resource Economics at Colby

This paper examines the effectiveness of the Colby College electricity reduction competition in altering students’ behavior to conserve electricity. The Colby College electricity reduction competition is an information-based policy that Colby implemented to promote the conservation of electricity, which are a major contributor to greenhouse gas (GHG) emissions in the United States. The study analyzes if different residence halls reduce electricity consumption by different amounts during the competition period. Results indicate that only 4 of 22 residence halls reduced electricity usage during competition periods in a statistically significant manner. The study concludes that the electricity competition at Colby College is …


Invited Introduction To Jerec, Matthew Kotchen Jan 2016

Invited Introduction To Jerec, Matthew Kotchen

Journal of Environmental and Resource Economics at Colby

No abstract provided.


Welcome By The Editor, Nathan W. Chan Jan 2016

Welcome By The Editor, Nathan W. Chan

Journal of Environmental and Resource Economics at Colby

No abstract provided.


Molecular Docking Study Of Tyrosinase Inhibitors Using Arguslab 4.0.1 : A Comparative Study, Prasan Tangyuenyongwatana, Nathjanan Jongkon Jan 2016

Molecular Docking Study Of Tyrosinase Inhibitors Using Arguslab 4.0.1 : A Comparative Study, Prasan Tangyuenyongwatana, Nathjanan Jongkon

The Thai Journal of Pharmaceutical Sciences

We conducted a docking study with ArgusLab 4.0.1, a free molecular docking software, on tyrosinase inhibitors comparing with AutoDock 4 and AutoDock VINA. In this study, hydroxyl substituted 2-phenyl-naphthalenes (a group of modified structure based on o...


Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain, Amit Kumar, Kundan Singh Bora, Amteshwar Singh Jaggi, Richa Shri Jan 2016

Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain, Amit Kumar, Kundan Singh Bora, Amteshwar Singh Jaggi, Richa Shri

The Thai Journal of Pharmaceutical Sciences

Objectives: Allium cepa has been used extensively for culinary purposes as well as in traditional system of medicine. A number of varieties of A. cepa are available commercially with varietal differences in phytoconstituents and biological activities. Ho...


Validation Of An Rp-Hplc Method For Quantitative Analysis Of Phikud Navakot Extract Using The Standard Addition Method, Pavena Kumnerdnon, Pornchai Rojsitthisak, Nuansri Niwattisaiwong, Uthai Sotanaphun, Jittima Chatchawalsaisin, Narueporn Sutanthavibul Jan 2016

Validation Of An Rp-Hplc Method For Quantitative Analysis Of Phikud Navakot Extract Using The Standard Addition Method, Pavena Kumnerdnon, Pornchai Rojsitthisak, Nuansri Niwattisaiwong, Uthai Sotanaphun, Jittima Chatchawalsaisin, Narueporn Sutanthavibul

The Thai Journal of Pharmaceutical Sciences

The aim of the study was to develop a reversed phase-high performance liquid chromatography (RP-HPLC) analytical method for monitoring three analytical markers, gallic acid, vanillic acid and ferulic acid, in Phikud Navakot extract (NVK-E), using the sta...


Tlc-Densitometric Method For Quantitation Of Lurasidone Hydrochloride In Nanoemulsion, Microemulsion, For Equilibrium Solubility And Ex Vivo Diffusion Studies., Rashmin B. Patel, Khyati B. Vekaria, Mrunali R. Patel Jan 2016

Tlc-Densitometric Method For Quantitation Of Lurasidone Hydrochloride In Nanoemulsion, Microemulsion, For Equilibrium Solubility And Ex Vivo Diffusion Studies., Rashmin B. Patel, Khyati B. Vekaria, Mrunali R. Patel

The Thai Journal of Pharmaceutical Sciences

A new TLC-densitometric method has been successfully developed for quantitation of Lurasidone hydrochloride (LURHA) in pharmaceutical formulations. LURHA was well separated from sample matrix and degradation product using TLC plate; precoated with silica...


Effect Of Time-Dependent Polymer On The Dissolution Rate Of Flurbiprofen: Formulation And Evaluation Of Colon-Specific Matrix Tablets, Sateesh Kumar Vemula, Selamu Kebamo, Balisa Mosisa, Biniam Paulos Jan 2016

Effect Of Time-Dependent Polymer On The Dissolution Rate Of Flurbiprofen: Formulation And Evaluation Of Colon-Specific Matrix Tablets, Sateesh Kumar Vemula, Selamu Kebamo, Balisa Mosisa, Biniam Paulos

The Thai Journal of Pharmaceutical Sciences

An effort was made in the present study to prepare flurbiprofen matrix tablets to improve the therapeutic efficacy by increasing therapeutic drug concentrations in lower intestine i.e., site-specific release to colon. The current experiment was aimed to ...


Comparison Of Sedimentation Stability Of Ampicillin Trihydrate Suspensions Using Near Infrared Extinction Profiles, Padala Narasimha Murthy, Meduri Vimala Devi, Sudhir Kumar Sahoo, Anjan Kumar Mahapatra, Madhusmruti Khandai Jan 2016

Comparison Of Sedimentation Stability Of Ampicillin Trihydrate Suspensions Using Near Infrared Extinction Profiles, Padala Narasimha Murthy, Meduri Vimala Devi, Sudhir Kumar Sahoo, Anjan Kumar Mahapatra, Madhusmruti Khandai

The Thai Journal of Pharmaceutical Sciences

Suspensions are one of the most important and popular dosage forms. A large number of drugs are formulated in the form of suspensions and are available commercially. Stability studies of suspensions are very important to enable the patient to receive t...


Qsar Study On Quinolinecarbaldehyde Derivatives As Potential Anti-Tubercular Agents, Ravichandran Veerasamy, Shalini Sivadasan, Venakteskumar Krishnamoorthi, Harish Rajak, Sureshkumar Krishnan Jan 2016

Qsar Study On Quinolinecarbaldehyde Derivatives As Potential Anti-Tubercular Agents, Ravichandran Veerasamy, Shalini Sivadasan, Venakteskumar Krishnamoorthi, Harish Rajak, Sureshkumar Krishnan

The Thai Journal of Pharmaceutical Sciences

This study investigated the quantitative structure–activity relationships (QSAR) for a range of substituted quinolinecarbaldehyde derivatives as anti-tubercular agent by multiple linear regression analysis. The derived QSAR models have been statistical...


Cross Immediate Hypersensitivity Between Ciprofloxacin And Levofloxacin: A Case Report And Literature Review, Chotirat Nakaranurack Jan 2016

Cross Immediate Hypersensitivity Between Ciprofloxacin And Levofloxacin: A Case Report And Literature Review, Chotirat Nakaranurack

The Thai Journal of Pharmaceutical Sciences

Fluoroquinolones can show cross-reactivity because of the similar chemical structure. Levofloxacin is a new fluoroquinolone and can be a safe alternative due to low cross-reactivity. This is a case report showing cross-reactivity between ciprofloxacin an...


Development Of Miconazole Nitrate Loaded Micellar Gel For Improved Topical Delivery, Manish Kumar Jan 2016

Development Of Miconazole Nitrate Loaded Micellar Gel For Improved Topical Delivery, Manish Kumar

The Thai Journal of Pharmaceutical Sciences

The objective of the present investigation was to develop micellar gel of miconazole nitrate using amphiphilic block co-polymer pluronic F-127. Miconazole nitrate was entrapped into the micelles at critical micelle concentration by dialysis method and F2...


Exploring Knowledge Acquisition Technique For New Start-Up Community Food Enterprises, Wattanapong Luechoowong, Ruangthip Tantipidoke, Rungpetch Sakulbumrungsil Jan 2016

Exploring Knowledge Acquisition Technique For New Start-Up Community Food Enterprises, Wattanapong Luechoowong, Ruangthip Tantipidoke, Rungpetch Sakulbumrungsil

The Thai Journal of Pharmaceutical Sciences

Objective: This qualitative study is conducted to explore the knowledge acquisition techniques from five successful food enterprises at the new entry of community business. Methods: Five successful community food producers were purposively selected unde...


Developing A Signal Triage Algorithm For Thai National Adverse Drug Reaction Database, Suntharee T. Chaisumritchoke Jan 2016

Developing A Signal Triage Algorithm For Thai National Adverse Drug Reaction Database, Suntharee T. Chaisumritchoke

The Thai Journal of Pharmaceutical Sciences

There was increasing adverse drug reaction (ADR) reports submitted to the Health Product Vigilance Center under the Thai FDA. In order to find some signals, the Thai Signal Detection Program was developed to identify and filter the potential signals, cal...


Factors Affecting Community Pharmacists’ Intention To Provide Medication Management Program And Disease Screening In Bangkok, Payungjit Kangwol, Puree Anantachoti Jan 2016

Factors Affecting Community Pharmacists’ Intention To Provide Medication Management Program And Disease Screening In Bangkok, Payungjit Kangwol, Puree Anantachoti

The Thai Journal of Pharmaceutical Sciences

Objectives: To determine factors affecting community pharmacists’ intention to provide medication management program (MMP) and disease screening (DS) based on diffusion of innovations theory. Methods: A cross-sectional study using self-administered ma...