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Modulation Of Estrogen Metabolism And Prevention Of Pathologies, Bodhisattwa Mondal
Modulation Of Estrogen Metabolism And Prevention Of Pathologies, Bodhisattwa Mondal
Theses & Dissertations
Estrogens have been implicated in non-cancerous pathologies such as Fuchs Endothelial Corneal Dystrophy (FECD), and accumulating evidence suggests estrogen genotoxicity leads to initiation of multiple types of cancer among Caucasian populations. These studies were mono-racial, and restoration of estrogen metabolism imbalance using naturally occurring compounds were not definitive. Therefore, the role of estrogen metabolism in FECD, in cancer initiation among African American (AA) populations, its modulation by environmental toxicant arsenic trioxide (As2O3), and by antioxidants polydatin (PD) and resveratrol were explored.
In human breast epithelial non-transformed MCF10A cells, As2O3 – induced cytotoxicity was …