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Development Of Chloroquine-Containing Hpma Copolymers For Drug Delivery, Fei Yu
Development Of Chloroquine-Containing Hpma Copolymers For Drug Delivery, Fei Yu
Theses & Dissertations
Abstract
Development of Chloroquine-containing HPMA Copolymers for Drug Delivery
Fei Yu, Ph.D.
University of Nebraska Medical Center, 2018
Supervisor: David Oupický, Ph.D.
Synthetic polymers have been extensively explored for improved delivery of anticancer agents. Polymers can be designed as either carriers of existing drugs or as polymeric drugs with intrinsic pharmacological activity. Advantages of such polymeric drugs include common positive features of polymer-drug conjugates, such as targeted delivery of drugs, altered pharmacokinetic and biodistribution, improved drug safety, but also favorable pharmacological activities due to multivalent receptor-ligand interactions.
Chloroquine (CQ) and hydroxychloroquine (HCQ) are safe drugs that have been in clinical …