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Pharmacology, Toxicology and Environmental Health

Journal of the Arkansas Academy of Science

Journal

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Full-Text Articles in Life Sciences

Organochloride Pesticides Present In Animal Fur, Soil, And Streambed In An Agricultural Region Of Southeastern Arkansas, Matthew E. Grilliot, John L. Hunt, Christopher G. Sims Jan 2018

Organochloride Pesticides Present In Animal Fur, Soil, And Streambed In An Agricultural Region Of Southeastern Arkansas, Matthew E. Grilliot, John L. Hunt, Christopher G. Sims

Journal of the Arkansas Academy of Science

Animals in agricultural settings may be subject to bioaccumulation of toxins. For the last several years, we collected hair samples from bats and rodents in an agricultural area near Bayou Bartholomew in Drew County, Arkansas. Samples were submitted to the Center of Environmental Sciences and Engineering at the University of Connecticut for wide-screen toxin analysis. Several of these samples contained measurable amounts of organochloride pesticides or their metabolites, including some that have been banned for decades, such as dichlorodiphenyltrichloroethane (DDT) and chlordane. In addition, we collected several samples of soil from within an agricultural field, from adjacent edge habitat, from …


Oxidation-Reduction Characteristics Of Chlorophenols In An Aprotic Medium, Cecil A. Sorrells, Ali U. Shaikh, Victor M. Samokyszyn Jan 2002

Oxidation-Reduction Characteristics Of Chlorophenols In An Aprotic Medium, Cecil A. Sorrells, Ali U. Shaikh, Victor M. Samokyszyn

Journal of the Arkansas Academy of Science

Eighteen chlorophenols, containing from one to five chlorine atoms on the benzene ring at various positions, have been studied by cyclic voltammetric methods to evaluate their oxidation-reduction characteristics in an aprotic medium. The compounds were dissolved in dimethylsulfoxide containing 0.10 M tetrabutylammonium perchlorate as the supporting electrolyte and were then both oxidized and reduced on a glassy carbon electrode. The results indicate that phenols oxidize in a one-step process to phenoxium ion which dimerizes to quinone ether. The ether can be reduced back to phenol in a two-step reduction process. The oxidation potential of the chlorophenols varies with the number …


Blood Levels Of 5-Bromo-2'-Deoxyuridine In Intraperitoneal Infusion For Determination Of Sister Chromatid Exchange Induction Using Hplc, Angelo Turturro, Narendra P. Singh, Johnny Bazare Jr., Ronald W. Hart Jan 1982

Blood Levels Of 5-Bromo-2'-Deoxyuridine In Intraperitoneal Infusion For Determination Of Sister Chromatid Exchange Induction Using Hplc, Angelo Turturro, Narendra P. Singh, Johnny Bazare Jr., Ronald W. Hart

Journal of the Arkansas Academy of Science

A new technique was developed to measure the amount of 5-bromo-2 '-deoxyurdine (BrdUrd), a thymidine analogue, rapidly and conveniently in blood, and it was applied to measure the concentration of BrdUrd during the initiation of a paradigm for the labeling of DNA to measure the induction of sister chromatid exchanges (SCE) by genotoxic agents. Radio labelled BrdUrd was used and blood was drawn from the abdominal aorta in pregnant Sprague-Dawley derived D rats. Using the hplc, the BrdUrd peak was easily identifiable and separable from its metabolites. The BrdUrd level in the blood stabilized in 30 minutes, and a level …