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Pharmacology, Toxicology and Environmental Health
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
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Molecular Toxicology Of Pyrrolizidine Alkaloids, Hea-Young Kim
Molecular Toxicology Of Pyrrolizidine Alkaloids, Hea-Young Kim
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Pyrrolizidine alkaloids are cytotoxic, carcinogenic, and anti-carcinogenic in vivo and in vitro, and they produce many hazardous effects in humans and animals. Pyrrolizidine alkaloids (PAs) also cross-link with DNA and/or protein. However, whether such cross-linking is important to the toxic action of PAs is not known. In addition, the exact mechanism underlying these DNA cross-links or cytotoxicity is also not clear.
In three separate studies, I characterized the nature of PA-induced DNA cross-links and the relationships between PA structures and cross-linking potency. In the first study (Chapter II), I found that cross-linking potency of PA congeners coincided with their …