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The Effect Of Oatp2b1-Mediated Statin Transport On Beta Cell Dysfunction, Jihoon Kwon
The Effect Of Oatp2b1-Mediated Statin Transport On Beta Cell Dysfunction, Jihoon Kwon
Electronic Thesis and Dissertation Repository
Statins are a class of cholesterol-lowering drugs which work by inhibiting the mevalonate pathway. Statin treatment has been linked to an increase in the risk of new-onset diabetes mellitus, and previous studies have suggested impairment in insulin secretion following statin treatment. Recent work from our laboratory confirmed the expression of organic anion transporting polypeptide 2B1 (OATP2B1), an important statin uptake transporter, in human pancreatic beta cells. Our study examined the role of OATP2B1 in statin-associated beta cell toxicity using INS-1 cells as a beta cell model. We showed that OATP2B1 augments cellular accumulation of rosuvastatin and atorvastatin, but not pravastatin. …
The Role Of Oatp-Mediated Statin Transport In Pancreatic Beta Cell Function, Michelle S. Kim
The Role Of Oatp-Mediated Statin Transport In Pancreatic Beta Cell Function, Michelle S. Kim
Electronic Thesis and Dissertation Repository
Cholesterol-lowering statins, or the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are one of the leading treatments for hypercholesterolemia and are recognized for their ability to prevent cardiovascular events. Though safe and effective for most, statin therapy has recently been associated with new-onset diabetes, with risk varying depending on potency and dose. Additionally, in vitro data suggest statin-mediated alterations in insulin secretion; however, the exact mechanism is currently unknown. Statins are known substrates of various membrane transporters belonging to the organic anion-transporting polypeptides (OATPs), on which they rely heavily for hepatic uptake and therapeutic efficacy. We have recently reported expression of OATP1B3 …