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Dendrimer-Coated Iron Oxide Theranostic Nanoparticles For Cancer Imaging And Therapy, Duy Khanh Luong
Dendrimer-Coated Iron Oxide Theranostic Nanoparticles For Cancer Imaging And Therapy, Duy Khanh Luong
Wayne State University Theses
The bleak prognosis for patients diagnosed with metastatic cancer along with the low therapeutic efficacy and the recurrence of cancer in conventional chemotherapy are prompting clinical medicine to adopt a new strategy to detect cancer in early stage and to deliver the anticancer drugs specifically to tumor site to enhance therapeutic efficiency and minimize side effects. The aim of this study is to design a theranostic nanocarrier consisting of iron oxide nanoparticles (SPIONs) for magnetic resonance imaging (MRI) and Polyamidoamine dendrimers conjugated with folic acid (FA-PAMAM) for active targeted delivery of a highly potent but extremely lipophilic anticancer compound 3,4-difluorobenzylidene …