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Studying The Antagonistic Relationship Between Nkg2d And Tgf-Β Signaling In Cd8+ T Cells, Kushal Prajapati
Studying The Antagonistic Relationship Between Nkg2d And Tgf-Β Signaling In Cd8+ T Cells, Kushal Prajapati
Dissertations
Despite the remarkable success of cancer immunotherapies in treating patients with hematological cancers, the clinical response rates of immunotherapies in the case of solid tumors have been dismal. One major reason for the lower response rates is tumor-induced immune-suppression mediated by TGF-?, which directly suppresses the functionality of CD8+ T cells by inhibiting their activation, proliferation, and acquisition of inflammatory cytokines, granzyme B and perforin. On the other hand, NKG2D, a potent co-stimulatory receptor, has effects on CD8+ T cells opposite to that of TGF-?. In T cells from 22 healthy human donors, we found that the suppression by TGF-? …