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Full-Text Articles in Life Sciences
Addressing Environmental Gentrification: Improving Environmental Health For Children And Youth Without Displacement, Tania Schusler, Amy Krings
Addressing Environmental Gentrification: Improving Environmental Health For Children And Youth Without Displacement, Tania Schusler, Amy Krings
Social Work: School of Social Work Faculty Publications and Other Works
Historically, low income communities and communities of color have borne the brunt of environmental pollution with limited access to environmental amenities. This has arisen, in part, due to marginalized communities’ lack of access and influence in environmental decision making, as well as legacies of racial and ethnic housing segregation (Cole & Foster, 2001). Environmental justice concerns include the disproportionate placement and inequitable regulation of polluting facilities in areas populated by people who are poor and/or racial minorities (Bryant, 1995: Bullard, 1993; Mohai & Bryant, 1992; Lavelle & Coyle, 1992). The inequitable distribution of environmental pollution is especially problematic for children’s …
Studying The Antagonistic Relationship Between Nkg2d And Tgf-Β Signaling In Cd8+ T Cells, Kushal Prajapati
Studying The Antagonistic Relationship Between Nkg2d And Tgf-Β Signaling In Cd8+ T Cells, Kushal Prajapati
Dissertations
Despite the remarkable success of cancer immunotherapies in treating patients with hematological cancers, the clinical response rates of immunotherapies in the case of solid tumors have been dismal. One major reason for the lower response rates is tumor-induced immune-suppression mediated by TGF-?, which directly suppresses the functionality of CD8+ T cells by inhibiting their activation, proliferation, and acquisition of inflammatory cytokines, granzyme B and perforin. On the other hand, NKG2D, a potent co-stimulatory receptor, has effects on CD8+ T cells opposite to that of TGF-?. In T cells from 22 healthy human donors, we found that the suppression by TGF-? …