Life Sciences Commons^™

Cisplatin Ototoxicity In The Guinea Pig: An Electrophysiological, Morphological, And Biochemical Study, Sarah E. Barron

Electronic Theses and Dissertations

The purpose of this study was to determine changes induced by cisplatin on hair cell (HC) morphology, compound action potential (CAP), Preyer reflex (PR), and Na,K-ATPase activity in the cochlear lateral wall. Guinea pigs were treated with either 0.42, 0.83, 1.17, 1.50 mg/kg cisplatin, i.p. or sterile water for 12 consecutive days and tested on day 13. HC condition was visualized with scanning electron microscopy (SEM), CAP was initiated with a 1 volt click, and Na,K-ATPase activity was measured by the method of Fiske and SubbaRow. HC damage was linear with dose and occurred throughout the turns of the cochlea …

Seasonal Variation In Population Location Of The Galapagos Tortoise, Geochelone Elephantopus Vandenburghi, On Volcan Alcedo, Isabela Island, Galapagos Archipelago, Kent R. Beaman

Loma Linda University Electronic Theses, Dissertations & Projects

Twenty tortoises, 10 adult males and 10 adult females, were tagged with radio transmitters. Numbers were painted on each carapace to aid in visual sighting. The tortoises were released, and their movement was monitored over a one year period.

The percent recovery of tagged tortoises along with the numbers of non-tagged tortoises counted in sections of the study area, were used to determine tortoise population movement and location.

Weather data were collected and observations were made concerning the vegetation. These observations were compared with those from previous studies to see what impact seasonal climatic conditions and food availability had on …

Modification Of Chromium(Vi)-Induced Dna Damage By Glutathione And Cytochromes P-450 In Chicken Embryo Hepatocytes., Doreen Y. Cupo, Karen E. Wetterhahn

Dartmouth Scholarship

The role of glutathione and cytochrome P-450 in the production of DNA damage by chromium(VI) was examined in chicken embryo hepatocytes by the alkaline elution technique. Cellular levels of glutathione and cytochrome P-450 were altered by treating the hepatocytes with N-acetyl-L-cysteine, buthionine sulfoximine, isopentanol, or beta-naphthoflavone. A dramatic increase in chromium(VI)-induced DNA strand breaks was observed after increasing glutathione levels in the cells. Chromium(VI)-induced DNA strand breaks were even more numerous when the level of cytochrome P-450 was also increased. Upon depletion of glutathione levels and induction of cytochrome P-450 or cytochrome P-448, little or no DNA strand breaks or …

Microbial Characteristics Of An Industrial Mixed Liquor After Exposure To Phenolic Compounds, Patricia L. Boyle

Theses

The microbial characteristics of a mixed population from the Passaic Valley Sewerage Commissioners (PVSC) Wastewater Treatment Plant in Newark were examined. This plant handles about 250 million gallons per day of mixed sewerage, with a large industrial component. The microbial species were characterized using standard plating techniques, morphology, microscopic observation, and biochemical tests. These characteristics were determined for the fresh liquor, and after successive batch exposure to phenol (100 ppm) and 2-chlorophenol (20 ppm). Predator/prey, gram positive to gram negative bacteria ratios, and the fungi and protozoan populations were also determined. These results were compared with those previously obtained using …

Protective Laboratory Measures For The Flexible Wall Permeameter And The Atterberg Limits Tests Using Hazardous And Toxic Chemicals, Robert A. Tetla

Theses

Safety procedures for performing geotechnical testing with hazardous and toxic materials, excluding radioactive wastes, are developed for the Flexible Wall Permeameter and the Atterberg Limits Tests. The tests were evaluated in detail to determine the critical points at which the technician would be exposed to the hazardous and/or toxic permeant. It was found that the following safety measures should always be taken; 1) the apparatus and all testing should be undertaken in a sliding sash hood using the proper face velocity, 2) air monitoring using a personal dosimeter and/or a detector tube is required to assure that the concentration of …

The Kinetics And Hepatotoxicity Of Benzyl Chloride Vapor In Rats, Hari V. Rao

Theses

Male Sprague Dawley rats (250g) were exposed to benzyl chloride vapor at a concentration of 220 ppm for 6 hours. During inhalation, the blood benzyl chloride concentration increased to reach a steady state level of 9-10 ug/ml between 4 and 6 hours of exposure. A small concentration of benzyl chloride (0.86 ug/ml) was present in the blood four hours after the termination of exposure. The absorption half life was 0.53 hours (0.39-0.81) and the elimination half life was l.12 hour (0.93-l.40).

The absorbed benzyl chloride was largely retained in the blood and some of it (0.22 ug/g) was sequestered into …

Scheduling Effects Of 5-(3,3-Dimethyl-1-Triazeno)Imidazole-4-Carboxamide (Dtic) And 1,3-Bis-Chloroethyl-1-Nitrosourea (Bcnu) On Mouse Melanoma Cells B16cl5, Gracie V. Coffey

Theses

DTIC and BCNU have been demonstrated to have enhanced chemotherapeutic effects in mice bearing Bl6 mouse melanoma cells. The order of administration seems to be important in maintaining optimum effects. This was shown is a study by Hill et al. (unpublished).

In the present study, mouse melanoma cells, Bl6CL4, were treated with either DTIC or BCNU. The drug was allowed to remain on the cells for 2, 3, or 4 days. The drug-containing media were then removed, the cells were washed and fresh medium was added. The cells were incubated in an atmosphere of 5% CO2 and 95% air at …

Failure Of Opioids To Modify Noradrenergic Neuronal Recovery From A Dorsal Bundle Lesion In Neonatal Rats, Ellen L. Kunkel-Bagden

Electronic Theses and Dissertations

Morphine and exogenous opioid peptides alter the development of central noradrenergic neurons damaged by neonatal treatment with the neurotoxin 6-hydroxydopa. Transection of the dorsal noradrenergic bundle (DNB) in neonatal rats produces nearly the same alteration in the developmental pattern. It was of interest to determine whether morphine or an exogenous opioid peptide (metenkephalin) was able to modify the recovery of noradrenergic neurons after neonatal surgical transection of the DNB. Neonatal rats were divided into two groups. Both groups received saline (0.85%) or naloxone (2.0 mg/kg) by the intraperitoneal (i.p.) route. In the first group the animals received an additional i.p. …

Effects Of Antiepileptic Drugs On Immune Function In Human Subjects And Mice, Nadine C. Margaretten

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A number of immune abnormalities have been found in epileptic patients treated with antiepileptic drugs (AED). The alterations seen range from mild suppression of immunoglobulins to severly impaired humoral and cellular immunities. There is evidence for both drug effects and genetic or acquired factors as contributors to these abnormalities. In order to examine the basis for immune abnormalities in patients with epilepsy, a number of experimental designs were employed: clinical studies, in vitro studies, and use of an animal model.

Peripheral blood mononuclear cells (PBMC) isolated from epileptic patients currently receiving AED were found to have a reduced OKT4+/0KT8+ ratio. …

The Synthesis And Evaluation Of A New Analog Of Phencyclidine (Pcp), William H. Johnson Jr.

Chemistry & Biochemistry Theses & Dissertations

Based on an interpretation of the literature of phencyclidine (PCP) together with an examination of the relevant models or prototype structures, this research has attempted to design and synthesize a rigid analog of the phencyclidine structure. The parent ring systems suggested for this study were the 1-arnino and 2-arninornethyltetralins, 10 and, 12.

Several organic compounds, based on this design, have been prepared by classical examples of reductive alkylation reactions of the corresponding 2-hydroxyciethylene-1-tetralones, 11, and by the condensation and subsequent reductive alkylation of the 1-arninotetralin, 9. These arninomethyltetralones, 28, 29 and 30, together with an example of a substituted 1-arninotetralin, …

ข่าวงานวิจัยเห็๋ดแคลงกับเชลมะเร็ง, อนงค์ จันทร์ศรีกุล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

จากยาปฎิชีวนะที่รักษาโรคร้ายสู่โต๊ะอาหารอันโอชา, สุนันท์ พงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

เกณฑ์การเลือกชนิดของปลาเป็นสัตว์ทดลองทางพิษวิทยา, พาลาภ สิงหเสนี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The Survey Of Drug Utilization In University(การสำรวจการใช้ยาในโรงพยาบาลมหาวิทยาลัย ในกรุงเทพมหานคร ระหว่าง พ.ศ. 2523-2525), Daangchit Panomvana, Patipan Panomvana, Aphirudee Hemachudha

The Thai Journal of Pharmaceutical Sciences

The top 200 drug products most frequently dispensed in the university hospitals in Bangkok during 1980 to 1982 were identified and ranked. Paracetamol was ranked number one with the highest number of tablets dispensed while Ampicillin was ranked number o...

การรับประทานผงถ่าน ช่วยกำจัดสารพิษในกระแสเลือดได้, นุชรี เบญจานุวัตรา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ความสำเร็จขั้นแรกของอินเทอร์ฟีรอน, สุนันท์ พงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ลับสมอง, รศ. เรวดี, วราภรณ์ สุวกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Dihydrofolate Reductase In Human Cancers(ไดฮัยโดรโฟเลทรีดักเทสจากเนื้อเยื่อมะเร็งของคน), Kreawan Akraksasilapachai, Piya Buranasiri, Sunanta Pongsamart

The Thai Journal of Pharmaceutical Sciences

Dihydrofolate reductase activities of partially pyrified enzymes, by protamine sulfate precipitation, from human cancers of breast, lung, kidney, stomach, colon and rectum were determined by spectrophotometric assay. It was observed that all of tumorous ...

Growth Patterns In Some Vitamin Deficient Media Of Lactobacillus Species Isolated From Fermented Foods(รูปแบบการเจริญในอาหารที่ขาดวิตามินบางชนิด ของเชื้อ La..., Wongcare Jivatadavirute, Somboon Tanasupawat

The Thai Journal of Pharmaceutical Sciences

Growth in five vitamin deficient media of 44 isolates of Lactobacillus species isolated from fermented foods was determined. Each media was without one of the following five vitamins, thiamine, folic acid, niacin, biotin, or riboflavin respectively. Five...

ตัวยาออกฤทธิ์ชนิดใหม่สำหรับใช้ในการเตรียมยาลดกรด, เยาวภา ไวรักษ์สัตว์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ย่อยข่าวยา, สุนันท์ พงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Evaluation Of The Toxicity Of Contaminated Sediments In The James River, Virginia, Morris H. Roberts, Charles J. Strobel

Reports

The Virginia State Water Control.Board, in cooperation with the Department of Chemical Oceanography of the Virginia Institute of Marine Science has recently conducted periodic chemical surveys of organic pollutants in the sediments of the upper James River. The August 1983 survey showed elevated concentrations of polycyclic aromatic hydrocarbons (PAH) at Stations ·4 and 7 (Figure 1 and Table 1). Although the reported concentrations were approximately one order· of magnitude lower than those reported in contaminated areas of the Elizabeth River, they were deemed high enough to warrant_ further study based on reported toxicity of Elizabeth River sediments (Hargis et al. …

ถามมา-ตอบไป เรื่อง อาการไม่พึงประสงค์ของ Moxalactam, สุกัญญา นิมมานนิตย์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Protein Quality Of Wild Edible Mushrooms In Thailand(คุณค่าขอโปรตีนจากเห็ดธรรมชาติ ที่รับประทานได้ในประเทศไทย), Sunanta Pongsamart, Sureepan Boonvisut, Prasert Vooticumpree

The Thai Journal of Pharmaceutical Sciences

Protien nutritional quality of different species of wild edible mushrooms in Thailand was investgated. The test mushrooms were Boletus sp-, Geaster sp., Pleurotus sp., Russula delica Fr-, Termitomyces sp., and Tricholoma crassum. Almost all of fresh mush...

ถามมา-ตอบไป เรื่อง ความเข้ากันได้ของยาฉีด B Complex กับ Calcium Gluconate, สุกัญญา นิมมานนิตย์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

วิทยาการก้าวหน้า, สุนันท์ พงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ลับสมอง, รศ. เรวดี, วราภรณ์ สุวกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Antibiotic And Antiseptic Resistance Of Pseudomonas Aeruginosa Isolated From Hospitalized Patients And Hospital Environments I. A Comparative Study(การดื้อต่อยาปฏิชีวนะและยาฆ่าเชื้อใส..., Adisak Noonai, มาลิน จุลศิริ, นิติ สุขกวี

The Thai Journal of Pharmaceutical Sciences

A total of 300 and 205 isolates of Pseudomonas aeruginosa from hospitalized patients and hospital environments, respectively, were studied for their resistance to three antibiotics, i.e., carbenilin, moxalactam and tobramycin, and three antiseptics, i.e....

วิทยาการก้าวหน้า, สุนันท์ พงษ์สามารถ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.