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Full-Text Articles in Life Sciences

Effects Of Ivermectin And Perfluorobutanesulfonic Acid (Pfbs) On Lipid Metabolism, Weipeng Qi Oct 2019

Effects Of Ivermectin And Perfluorobutanesulfonic Acid (Pfbs) On Lipid Metabolism, Weipeng Qi

Doctoral Dissertations

Accumulating evidence has shown a link between environmental contaminants and altered lipid metabolism. There is currently, however, limited knowledge regarding the causal molecular mechanisms. Therefore, we investigated the molecular mechanisms of two environmental contaminants, ivermectin and perfluorobutanesulfonic acid (PFBS), on lipid metabolism in adipocytes and hepatocytes using cell culture models. We first studied the effects of ivermectin, an anti-parasitic agent, on the adipogenesis of 3T3-L1 preadipocytes. Our current results suggest that ivermectin inhibits adipogenesis in 3T3-L1 preadipocytes and the expression of adipogenic genes where these effects were found to be partially via PPARγ-dependent, but not FXR-dependent, pathway. Additionally, ivermectin also …


Optical Meets Mechanical: Use Of Luminescence Spectroscopy To Assess Ageing In Biodegradable Films, Louis Colaruotolo Oct 2019

Optical Meets Mechanical: Use Of Luminescence Spectroscopy To Assess Ageing In Biodegradable Films, Louis Colaruotolo

Masters Theses

With the growing concern of the accumulation of plastic-based food packaging waste, the search for bio-based biodegradable packages is on the rise. These materials differ from their petro-based counterparts in their degradation rates, which are much higher in the former. Not only do bio-based biodegradable materials degrade faster during post-usage processes but also they age faster during usage and storage, which affects their performance and functionality. The application of noninvasive testing methods with the capability to report on the matrix’s state could assist in the development of a more ubiquitous way to assess ageing in food packaging, particularly in biodegradable …


Prediction And Control Of Vitamin C Loss In Spaceflight Foods, William Dixon Mar 2019

Prediction And Control Of Vitamin C Loss In Spaceflight Foods, William Dixon

Doctoral Dissertations

Shelf stable foods that require no refrigeration or freezing are the predominant food source for astronauts. Due to its high impact on astronauts’ health, it is crucial to know if the astronauts are getting all the necessary nutrients from shelf stable foods, specifically vitamins. With limited knowledge on vitamin degradation in spaceflight foods during storage and processing, our team decided to tackle this issue focusing on unstable vitamins, which included vitamin C (ascorbic acid) and vitamin B1 (thiamine); however, this thesis will specifically focus on vitamin C. A two-year storage and retort processing study was conducted on 5 different foods …


Influence Of Shipping Container Upon Temperature, Relative Humidity, And Bacterial Growth On Broccoli, Nicholas Berus Mar 2019

Influence Of Shipping Container Upon Temperature, Relative Humidity, And Bacterial Growth On Broccoli, Nicholas Berus

Masters Theses

Temperature and relative humidity of produce throughout the cold chain can greatly affect the quality and safety of the food product. Different packaging systems or containers can provide better cooling environments for food products that could decrease temperature abuse and ultimately safety risks. In this study we compiled temperature and relative humidity profiles of broccoli packed in different shipping containers throughout the produce supply chain. The shipping containers looked at were the wax corrugated box, reusable plastic containers (RPC), and Eco Pack Green Box with and without a lid. Large differences were seen in the temperature profiles of each package …