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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Data-Driven Modeling Of The Causes And Effects Of Interneuronal Dysfunction In Alzheimer’S Disease And Dravet Syndrome, Carlos Perez
Data-Driven Modeling Of The Causes And Effects Of Interneuronal Dysfunction In Alzheimer’S Disease And Dravet Syndrome, Carlos Perez
USF Tampa Graduate Theses and Dissertations
One of the defining features of Alzheimer’s disease (AD) is the increased cleavage of the amyloid precursor protein (APP), causing abnormally high levels of the aggregation form of amyloid beta (Aβ ). Many studies have shown that both AD patients and AD mice models exhibit abnormal network activity, including hypersynchronous excitatory neuron behavior, altered brain rhythms, and in some instances epileptic seizures when exposed to high levels of Aβ In particular, strong experimental evidence suggests that it is the small globular amyloid oligomers (gOs) and curvilinear fibrils (CFs) rather than the more stable, late stage rigid fibrils (RFs) that cause …
Origins Of Amyloid Oligomers And Novel Approaches For Their Detection, Jeremy Barton
Origins Of Amyloid Oligomers And Novel Approaches For Their Detection, Jeremy Barton
USF Tampa Graduate Theses and Dissertations
Alzheimer’s disease, type II diabetes, and other amyloid diseases are known to be associated with the formation of amyloid aggregates. It has been thoroughly researched whether amyloid fibrils or oligomers are the main culprit for these diseases, and recent evidence has connected oligomers as the most disease relevant aggregate species. However, many difficulties have arose in confirming this hypothesis. Techniques for oligomer detection are often limited in their sensitivity, and in many cases are unable to distinguish oligomers from rigid fibrils. Additionally, the role oligomer splay in fibril assembly is still unclear, and has led to the belief that different …
Reproductive Ecology And Phenology Of Thalassia Testudinum (Hydrocharitaceae) In Tampa Bay, Florida, Sheila Scolaro
Reproductive Ecology And Phenology Of Thalassia Testudinum (Hydrocharitaceae) In Tampa Bay, Florida, Sheila Scolaro
USF Tampa Graduate Theses and Dissertations
Successful sexual reproduction and recolonization are critical in maintaining genetic diversity within seagrass meadows. Thalassia testudinum flower, fruit and seedling production were assessed visually at 10 sites within Tampa Bay, Florida approximately every 4 weeks from May to July 2017 to determine if there is spatial and temporal variation in sexual reproductive effort and if location within a meadow effects sexual reproductive effort. Results from this study reveal strong temporal variability throughout the reproductive season. The month of May was observed as peak Thalassia testudinum anthesis and June was peak fruiting in Tampa Bay during 2017. Flower and fruit density …
Swimming Of Pelagic Snails: Kinematics And Fluid Dynamics, Ferhat Karakas
Swimming Of Pelagic Snails: Kinematics And Fluid Dynamics, Ferhat Karakas
USF Tampa Graduate Theses and Dissertations
Pteropods (also known as sea butterflies or sea angels), are holoplanktonic marine snails which swim by flapping a pair of extremely flexible wings. The wings are modified from the molluscan foot and the wing motions are supported by the fluid pressure without any rigid support. Sea angels (gymnosome pteropods) are completely naked; in contrast, sea butterflies (thecosome pteropods) have negatively buoyant aragonite shells which vary in geometry and size among different species. Pteropods are seasonally abundant in the ocean, and an important food source for the other zooplanktons, fishes, and whales. Though studies have been conducted regarding their biology, ecology, …
Study Of The Therapeutic Effects Of Synchronization-Modulation Of The Na/K Pump On Muscle Fatigue, Jason E. Mast
Study Of The Therapeutic Effects Of Synchronization-Modulation Of The Na/K Pump On Muscle Fatigue, Jason E. Mast
USF Tampa Graduate Theses and Dissertations
It has been shown that by applying a specially designed oscillating external electric field to a cell membrane that the membrane's sodium/potassium pumps can be synchronized to all work at the same rate. Then by slowly increasing the electric field's frequency the pumps' turnover rate can also be increased. By increasing the pumps' turnover rate, the sodium and potassium concentration gradients can be increased, this type of stimulation is called synchronization-modulation. There are three generations of the synchronization-modulation waveform each with different utilities. In particular, the third generation of synchronization-modulation has the ability to use the energy of the external …
An Examination Of Changes In Muscle Thickness, Isometric Strength, And Body Water Throughout The Menstrual Cycle, Tayla E. Kuehne
An Examination Of Changes In Muscle Thickness, Isometric Strength, And Body Water Throughout The Menstrual Cycle, Tayla E. Kuehne
USF Tampa Graduate Theses and Dissertations
Women are often excluded from research studies interested in changes in muscle size and strength due to confounding influence that the menstrual cycle may have on these variables. Although there is considerable data showing that strength may fluctuate throughout the menstrual cycle, the thesis that muscle size changes throughout the cycle is based on the premise that changes in body water throughout the menstrual cycle may influence the size of the muscle. Despite this suggestion there is no experimental data demonstrating that the menstrual cycle has any influence on muscle size. Purpose: The purpose of this study is to examine …
Development And Application Of Computational Models For Biochemical Systems, Fiona L. Kearns
Development And Application Of Computational Models For Biochemical Systems, Fiona L. Kearns
USF Tampa Graduate Theses and Dissertations
Chemistry is the study of matter and its transformations. Computational chemistry uses computer models to study chemistry in all its intricate complexity. In this thesis I hope to accessibly introduce fundamental concepts central for computational chemistry including quantum mechanics, molecular mechanics, and multiscale modeling. I then present several works which I have conducted throughout my graduate career employing many different computational methods. The investigations described here can be summarized as follows. Chapter 2.1 modeling proteins involved in crustacean molting, and identifying possible inhibitors to this molting. Chapter 2.2 modeling d-fructose bound to synthetic saccharide receptors with hopes of improving saccharide …