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Carnitine Mediated Alterations Of Ethanol And Fatty Acid Metabolism, Randall L. Mynatt

Doctoral Dissertations

The purpose of this dissertation was to examine the effect of dietary carnitine supplementation on ethanol and fatty acid metabolism. Rats were fed Purina chow as such (non-supplemented, NS) or supplemented with 0.5% L-carnitine supplemented CS). Carnitine supplementation for 7d resulted in decreased oxidation of an oral dose of [1-¹⁴C]-ethanol. Expired ¹⁴CO₂ was significantly reduced at hours 4-12 in the CS group. There were no significant differences in urinary excretion of the ¹⁴C-label remaining in tissues after 12h was also not significantly affected by carnitine supplementation. Blood-ethanol concentrations (BEC) were 88.5 and 125.9 mg/dl in …