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Full-Text Articles in Life Sciences

Failure Of A Heterologous Recombinant Sca5/Ompb Protein-Based Vaccine To Elicit Effective Protective Immunity Against Rickettsia Rickettsii Infections In C3h/Hen Mice, Sean P. Riley, Marissa M. Cardwell, Yvonne G. Chan, Ludovic Pruneau, Fabio Del Piero, Juan J. Martinez Dec 2015

Failure Of A Heterologous Recombinant Sca5/Ompb Protein-Based Vaccine To Elicit Effective Protective Immunity Against Rickettsia Rickettsii Infections In C3h/Hen Mice, Sean P. Riley, Marissa M. Cardwell, Yvonne G. Chan, Ludovic Pruneau, Fabio Del Piero, Juan J. Martinez

Faculty Publications

Spotted fever group (SFG) rickettsial species are obligate intracellular tick-borne pathogens that are responsible for important human diseases. Previous reports have demonstrated the feasibility of using recombinant surface cell antigen Sca5/OmpB to elicit protective immunity against homologous challenges using murine models of Mediterranean spotted fever and Rocky Mountain spotted fever. In addition, the feasibility of generating cross-protective immunity against related rickettsial species has also been established, but the molecular basis for these phenomena was not explored. Here, we demonstrate that vaccination of C3H/HeN mice with a recombinant OmpB domain derived from Rickettsia conorii induced high titer humoral immune responses that …


First Successful Capture And Satellite Tracking Of A West Indian Manatee (Trichechus Manatus) In Panama: Feasibility Of Capture And Telemetry Techniques, Daniel Gonzalez-Socoloske, James P. Reid, Carlos Espinoza-Marin, Kherson E. Ruiz, Kenneth E. Glander, Leon David Olivera-Gomez Jan 2015

First Successful Capture And Satellite Tracking Of A West Indian Manatee (Trichechus Manatus) In Panama: Feasibility Of Capture And Telemetry Techniques, Daniel Gonzalez-Socoloske, James P. Reid, Carlos Espinoza-Marin, Kherson E. Ruiz, Kenneth E. Glander, Leon David Olivera-Gomez

Faculty Publications

It is currently unknown how important the Central American countries south of Belize are as a link between manatee populations in the north (Belize and Mexico) and populations in South America. Therefore, apart from knowing where manatees are found, it is important to understand how manatees are using these habitats and if they are moving between countries or distinct population centers. Here we report the results of a multi-national and multiinstitutional collaboration resulting in the first successful capture and satellite tracking of a West Indian manatee in southern Central America.