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Evaluation Of Orally Administered Sodium D-Thyroxine As A Teratogen In New Zealand White Rabbits, Gary A. Thibodeau

Electronic Theses and Dissertations

Sodium D-thyroxine was evaluated for possible embryotoxic and/or teratogenic effects following oral administration in New Zealand White rabbits. All animals utilized were alert, active and apparently disease-free virgin does weighing three and one-half to four kilograms. Rabbits were individually housed in stainless steel batteries and maintained on a commercially available palletized diet and mineral supplement. Feed and water were provided ad libitum in animal quarters air conditioned to minimize environmental temperature fluctuations. Following a 14-day post-delivery observation period does were bred to New Zealand White bucks and randomly allocated to one of two experimental groups or the control group each …