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Full-Text Articles in Life Sciences

Association Of Dietary Factors With Menstrual Cycle Characteristics, Radhika Natarajan Nov 2015

Association Of Dietary Factors With Menstrual Cycle Characteristics, Radhika Natarajan

Doctoral Dissertations

Abnormal menstrual cycle length, pattern and bleed duration are associated with reduced fecundity and increased risk of miscarriage. The menstrual cycle is governed by the hypothalamus-pituitary-ovarian (HPO) axis, and nutritional factors may affect menstrual characteristics by influencing the HPO axis. Identifying these factors may lead to cost effective ways to improve reproductive outcomes. In a cross-sectional analysis of 164 18- to 30-year-old women, we examined the association of adiposity, dietary fat intake and vitamin D status with menstrual cycle characteristics. Adiposity was measured using dual-energy X-ray absorptiometry (DXA); dietary intake was assessed using a food frequency questionnaire, and fasting venous …


The Effect Of Vitamin D Supplementation On Cardiovascular Risk Factors Among Minorities With Type 2 Diabetes, Joel Exebio Nov 2015

The Effect Of Vitamin D Supplementation On Cardiovascular Risk Factors Among Minorities With Type 2 Diabetes, Joel Exebio

FIU Electronic Theses and Dissertations

The aim of the present study was to determine the effect of vitamin D supplementation (4000 IU or 6000 IU of cholecalciferol daily for 6 months) on fasting plasma glucose, fasting insulin, glycated hemoglobin, and lipid profile in a sample of African-Americans and Hispanics with T2D and vitamin D insufficiency. Seventy five participants were recruited by community outreach. Plasma glucose concentration was measured by hexokinase enzymatic method. Glycated hemoglobin was measured by the DCA2000+ system. Insulin in fasting blood was determined by radioimmunoassay. Plasma total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein cholesterol were assayed by enzymatic methods. Serum vitamin …


Pregenomic And Genomic Effects Of 24,25-Dihydroxyvitamin D3, Yang Zhang May 2015

Pregenomic And Genomic Effects Of 24,25-Dihydroxyvitamin D3, Yang Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In the United States, the major dietary source of protein is poultry meat, particularly chicken. Phosphorus absorption in chickens is a critical problem in poultry production. It therefore is important to understand the cellular and molecular regulation of phosphorous absorption in intestine to increase efficiency of the process. This would provide the benefits of reducing feed costs and reducing phosphorous excretion, thereby contributing to the sustainability of agriculture in the United States. Therefore, the focus of this thesis is determining the effect of vitamin D metabolites involved in phosphate homeostasis using the chicken as a model.


Desensitization Of Hacat Keratinocytes To Vitamin D3 Occurs Via Loss Of Redd1 Regulation Of The Mtor Pathway, Michelle Leigh Jones Jan 2015

Desensitization Of Hacat Keratinocytes To Vitamin D3 Occurs Via Loss Of Redd1 Regulation Of The Mtor Pathway, Michelle Leigh Jones

Wayne State University Theses

Vitamin D3 treatment has long been considered in the treatment of cancer due to its well-documented anti-proliferative effects in vitro. While clinical studies have been positive in other cancers, results are inconclusive in cases of basal cell carcinoma. To better understand the reasons underlying this disconnect, this study employs an immortalized human keratinocyte cell line (HaCaT) to observe the effects of vitamin D3 treatment on cellular proliferation. The results show that both activate vitamin D3 (calcitriol) and its precursor (cholecalciferol) increase proliferation of these cells. Real-time PCR and western blot data indicate that the mTOR pathway becomes activated despite increased …