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Allometric Scaling Of Dietary Linoleic Acid On Changes In Tissue Arachidonic Acid Using Human Equivalent Diets In Mice, Kylie A Weldon
Allometric Scaling Of Dietary Linoleic Acid On Changes In Tissue Arachidonic Acid Using Human Equivalent Diets In Mice, Kylie A Weldon
Masters Theses
The ability to extrapolate nutritional intervention data from experimental rodent models to humans requires standardization of dietary design. The inability to translate the level of nutrients from animal models to humans has contributed to contradictory findings between species. It is hypothesized that dietary linoleic acid (LA) promotes chronic and acute diseases by enriching tissues with arachidonic acid (AA), its downstream metabolite. However, levels of LA in rodent diets are notoriously erratic making interspecies comparisons unreliable. Therefore, the ability to extrapolate the biological effects of dietary LA from experimental rodents to humans necessitates an allometric scaling model that is rooted within …