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Angiotensin Iv And The Molecular Mechanisms Involved In The Development Of Insulin Resistance In 3t3-L1 Adipocytes, Julie Anne Jungwirth
Angiotensin Iv And The Molecular Mechanisms Involved In The Development Of Insulin Resistance In 3t3-L1 Adipocytes, Julie Anne Jungwirth
Masters Theses
This study explored angiotensin IV’s (Ang IV) affects on the signaling pathways involved in the development of insulin resistance in 3T3-L1 adipocytes. Ang IV, working through the AT4 receptor, interferes with insulin signaling through the blockade of the phosphatidylinositol 3-kinases (PI3K)/Akt pathway and through activating mitogen activated protein kinases (MAPK): extracellular signal regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) which are known to impair insulin receptor substrate-1 (IRS-1) signaling. The expression of AT4 receptors was confirmed by reverse transcription polymerase chain reaction. Ang IV’s effects were found by treating adipocytes with combinations of Ang IV, AT …