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Full-Text Articles in Life Sciences
Validation Of Monitoring Septic Thymus Involution In Mice Using Ultrasound., Jianyao Xue, Xiang-An Li
Validation Of Monitoring Septic Thymus Involution In Mice Using Ultrasound., Jianyao Xue, Xiang-An Li
Journal of Pharmacology & Nutritional Sciences
Sepsis is a dangerous condition commonly seen in the intensive care unit (ICU) of hospitals. It causes the thymus, a crucial immune organ, to shrink. This process is known as thymus involution. Although thymus involution is a natural process that occurs as we age, it is accelerated during sepsis. This process is associated with poor outcomes in septic patients, yet it had never been studied using ultrasonography in a septic mouse model. Researchers from the University of Kentucky have validated a non-invasive ultrasound imaging approach to monitor septic thymus involution in a cecum ligation and puncture (CLP) sepsis mouse model. …
The Last Of Us In Therapy: How Mind-Controlling Fungi And Gut Bacteria Affect Your Mental Health, Anastasia Lyon
The Last Of Us In Therapy: How Mind-Controlling Fungi And Gut Bacteria Affect Your Mental Health, Anastasia Lyon
Journal of Pharmacology & Nutritional Sciences
The "psilocybiome" represents the mutually beneficial relationship between ourselves, our bacteria, and psychedelic drugs. This short review briefly discusses the benefits and limitations surrounding the potential for psychedelic therapy to synergize with gut bacteria to help regulate and maintain proper balance in the immune system, diet, and stress levels. Psychedelic therapy is a novel treatment strategy that has the potential to improve patient mental health, and, by identifying the types of gut bacteria present in patients, it can aid in personalizing medicine by determining how well their "psilocybiome" may respond.
(Pro)Renin Receptor And Its Soluble Form In Metabolic Dysfunction: Friend Or Foe?, Gertrude Arthur
(Pro)Renin Receptor And Its Soluble Form In Metabolic Dysfunction: Friend Or Foe?, Gertrude Arthur
Journal of Pharmacology & Nutritional Sciences
(Pro)renin receptor is component of the renin angiotensin system which has been shown to be involved in several physiological and pathophysiological processes including blood pressure regulation and hypertension, water and electrolyte balance, kidney injury, obesity, and metabolic dysfunction. Enzymatic cleavage of prorenin receptor produces soluble prorenin receptor which can also activate the renin angiotensin system stimulate similar pathophysiological process like its full form receptor. This review explores findings on the role of prorenin receptor and soluble prorenin receptor in metabolic dysfunction and discusses the conflicting findings on soluble prorenin receptor in metabolic dysfunction.
Nutritional & Colorectal Health, Tariq A. Alam, Brittany R. Rice, Sara B. Police
Nutritional & Colorectal Health, Tariq A. Alam, Brittany R. Rice, Sara B. Police
Journal of Pharmacology & Nutritional Sciences
Kentucky has the highest incidence and mortality rate of all site cancers, and Kentuckians residing in the Appalachian region often have worse outcomes, where cancer is a leading cause of death. Focusing on colorectal cancer (CRC) specifically, Kentucky ranks first nationwide for incidence (50 cases per 100,000 people) and fifth for mortality (about 17 deaths per 100,000 people). The Kentucky Colon Cancer Screening Program increased screening rates and reduced mortality since its launch. Yet, CRC remains a leading cause of death for Kentuckians. Risk factors for CRC include increasing age as well as a history of inflammatory bowel disease (IBD) …